Search results for: Yongchun Cui

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article

Evaluation on safety and efficacy of ultrasound assisted thrombolysis in a sheep artificial heart pump

Yongchun Cui, Xiaobing Zheng, Shuo Wang, Jianye Zhou, more

Biocybernetics and Biomedical Engineering > 2024 > Vol. 44, no. 2 > 277--285

Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the in-vitro experiments, the sonothrombolysis...

article

Construction and application of service quality evaluation system in the preclinical research on cardiovascular implant devices

Yongchun Cui, Fuliang Luo, Boqing Yang, Bin Li, more

BMC Medical Informatics and Decision Making > 2019 > 19 > 1 > 1-10

Background Services for the preclinical development and evaluation of cardiovascular implant devices (CVIDs) is a new industry. However, there is still no indicator system for quality evaluation. Our aim is to construct a service for quality evaluation system for the preclinical research and development of CVIDs based on Fuzzy Analytical Hierarchy Process (FAHP). Methods First, we reviewed the related...

article

Mdivi-1 alleviates blood-brain barrier disruption and cell death in experimental traumatic brain injury by mitigating autophagy dysfunction and mitophagy activation

Qiong Wu, Cheng Gao, Haochen Wang, Xinmu Zhang, more

The International Journal of Biochemistry & Cell Biology > 2018 > 94 > C > 44-55

Dynamin-related protein 1 (Drp1) is a key regulator of mitochondrial fission. Our previous studies proved that the inhibition of Drp1 may help attenuate traumatic brain injury (TBI)-induced functional outcome and cell death through maintaining normal mitochondrial morphology and inhibiting activation of apoptosis. However, the molecular mechanisms of Drp1 after TBI remain poorly understood. In this...

article

A Secure and High-Fidelity Live Animal Model for Off-Pump Coronary Bypass Surgery Training

Xiaopeng Liu, Yan Yang, Qiang Meng, Jiakang Sun, more

Journal of Surgical Education > 2016 > 73 > 4 > 583-588

Existing simulators for off-pump coronary artery (CA) bypass grafting training are unable to provide cardiac surgery residents all necessary skills they need entering the operation room. In this study, we introduced a secure and high-fidelity live animal model to supplement the in vitro simulators for off-pump CA bypass grafting training.The left internal thoracic artery (ITA) of 3 Chinese miniature...

article

Causal effect of vitamin D on prostate cancer using Mendelian randomization approach

Haining Yu, Peng Xu, Yongchun Cui

World Journal of Urology > 2016 > 34 > 4 > 613-614

article

Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress

Xiaopeng Liu, Yue Tang, Yongchun Cui, Hong Zhang, more

Journal of Biomedical Science > 2016 > 23 > 1 > 1-11

Background Autophagy participates in plaque formation and progression; however, its association with foam cells’ fate is unknown. To investigate autophagy features and its effect on the fate of different-stage macrophage foam cells (FCs). Different-stage FCs were obtained through incubation of THP-1 macrophages (THP-M) with oxidized low-density lipoprotein LDL (oxLDL, 80 μg/mL) for various durations...

article

miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

Mingjun Zhang, Xiaolei Wang, Wanhu Li, Yongchun Cui

Biochemical and Biophysical Research Communications > 2015 > 460 > 3 > 806-812

Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two...

article

Genetic polymorphisms in cytochrome P450 and clinical outcomes of FOLFIRI chemotherapy in patients with metastatic colorectal cancer

Ningning Dong, Fandong Meng, Yongdong Wu, Mingyu Wang, more

Tumor Biology > 2015 > 36 > 10 > 7691-7698

The purpose of this study is to evaluate the influence of germline polymorphisms of cytochrome P450 (CYP450) on objective response, progression-free survival (PFS) and overall suruvival (OS) in metastatic colorectal cancer (mCRC) receiving the combination chemotherapy of irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI). All SNPs in CYP450, whose minor allele frequency were more than 10 %, were...

article

Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer

Ningning Dong, Mingyu Wang, Huiqing Li, Yongchun Cui, more

Cancer Chemotherapy and Pharmacology > 2012 > 69 > 5 > 1315-1322

Purpose To evaluate the efficacy and safety of gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer (MBC). Patients and methods Elderly patients with MBC received gemcitabine 1,000 mg m⁻² and vinorelbine 25 mg m⁻² on days 1 and 8 every 3 weeks for a maximum of 6 cycles. The primary end points were objective response and...

article

Relationship Between Oxidized LDL Antibodies and Different Stages of Esophageal Carcinoma

Yan Wang, Hao Li, Yutao Diao, Huiqing Li, more

Archives of Medical Research > 2008 > 39 > 8 > 760-767

The aim of the study was to evaluate the association of antibodies against oxidized low-density lipoproteins (oxLDL-Ab) with esophageal carcinogenic progression.All 40- to 69-year-old residents from Feicheng were screened for esophageal lesions by endoscopic staining with 1.2% iodine solution combined with pathological evaluations. In this study there were 33 controls with normal esophageal squamous...

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