Search results for: Xavier Bertagna

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article

Comment on: “Levothyrox^® New and Old Formulations: Are they Switchable for Millions of Patients?”

Joël Coste, Xavier Bertagna, Mahmoud Zureik

Clinical Pharmacokinetics > 2019 > 58 > 7 > 965-966

This comment refers to the article available at https://doi.org/10.1007/s40262-019-00747-3 .

chapter

Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease

Guillaume Assie, Laurence Guignat, Jérôme Bertherat, Xavier Bertagna

Endocrine Updates > Cushing's Disease > 237-245

Since Don Nelson’s first description in 1958 of a pituitary macroadenoma occurring after adrenalectomy in a patient with Cushing’s disease, the “Nelson’s syndrome” has long been feared. However, major advances including pituitary MRI imaging, transsphenoidal surgery, and improvements in radiotherapy have changed the way Corticotroph Tumor Progression (CTP) can be monitored and treated. This chapter...

chapter

Revisiting the Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease

Guillaume Assie, Laurence Guignat, Jérôme Bertherat, Xavier Bertagna

Contemporary Endocrinology > Cushing's Syndrome > 177-187

Summary Since Don Nelson’s first description in 1958 of a pituitary macroadenoma occurring after adrenalectomy in a patient with Cushing’s disease, the “Nelson’s syndrome” has long been feared. However, major medical advances, such as pituitary imaging with MRI, surgery by the transsphenoidal route, and safe radiotherapy, have changed the way corticotroph tumor progression (CTP) can be monitored and...

chapter

The ENS@T Initiative

Xavier Bertagna

Adrenocortical Carcinoma > Adrenal Cancer Networks and Registries > 521-531

There are special circumstances related to the study of rare disease entities, such as ACC. It is crucial to combine clinical forces, if not simply to collect enough clinical material. There is no other way to (1) engage enough patients in clinical trials to establish genotype–phenotype correlations, (2) to catalogue a library of mutations and (3) to establish new prognostic markers. However, the...

article

Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing’s disease

Maria Fleseriu, Rosario Pivonello, Jacques Young, Amir H. Hamrahian, more

Pituitary > 2016 > 19 > 2 > 138-148

Purpose In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with Cushing’s disease. The current 22-week study (LINC 2; NCT01331239) further evaluated osilodrostat in patients with Cushing’s disease. Methods Phase II, open-label, prospective study of two patient cohorts. Follow-up cohort:...

article

Rasch analysis for assessing unidimensionality and identifying measurement biases of malignancy scores in oncology. The example of the Weiss histopathological system for the diagnosis of adrenocortical cancer

Joël Coste, Frédérique Tissier, Jacques Pouchot, Emmanuel Ecosse, more

Cancer Epidemiology > 2014 > 38 > 2 > 200-208

Many malignancy scores have been developed without comprehensive statistical or measurement validation, and in particular without verification of the necessary property of unidimensionality. Here, we used Rasch analysis to assess unidimensionality and identify measurement biases of malignancy scores.The Weiss histopathological system (WHS), summing nine items of histopathological alteration, was used...

article

Bronchial Carcinoid Tumors Causing Cushing's Syndrome: More Aggressive Behavior and the Need for Early Diagnosis

Guillaume Boddaert, Bertrand Grand, Francoise Le Pimpec-Barthes, Aurélie Cazes, more

The Annals of Thoracic Surgery > 2012 > 94 > 6 > 1823-1829

The aim of this study was to revisit the characteristics and outcomes of adrenocorticotropin-secreting bronchial carcinoid tumor (BCT) responsible for Cushing's syndrome (CS). We conducted a single-institution retrospective review of 14 patients who underwent pulmonary resection for BCT that presented as CS from October 1993 to November 2011. The group consisted of 8 male patients (57%) and...

article

Preface

Xavier Bertagna

Best Practice & Research Clinical Endocrinology & Metabolism > 2010 > 24 > 6 > vii

article

The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses

Guillaume Assié, Marine Guillaud-Bataille, Bruno Ragazzon, Xavier Bertagna, more

Trends in Endocrinology & Metabolism > 2010 > 21 > 5 > 325-334

Analyzing gene expression (transcriptome) in tissue is now reliable using industrial pangenomic microarrays. Accumulating data on adrenal cortex and adrenocortical tumor transcriptomes have already identified striking transcriptome differences not only between adenoma and carcinoma but also between two sets of carcinoma, which have very different prognoses. These findings result in the development...

article

Mutations and polymorphisms in the gene encoding regulatory subunit type 1‐alpha of protein kinase A (PRKAR1A): an update

Anélia Horvath, Jérôme Bertherat, Lionel Groussin, Marine Guillaud‐Bataille, more

Human Mutation > 31 > 4 > 369 - 379

PRKAR1A encodes the regulatory subunit type 1‐alpha (RIα) of the cyclic adenosine monophosphate (cAMP)‐dependent protein kinase (PKA). Inactivating PRKAR1A mutations are known to be responsible for the multiple neoplasia and lentiginosis syndrome Carney complex (CNC). To date, at least 117 pathogenic variants in PRKAR1A have been identified (online database: http://prkar1a.nichd.nih.gov). The majority...

article

Unexpected diagnosis for an adrenal tumor: synovial sarcoma

Pierre-Alexandre Just, Frédérique Tissier, Stéphane Silvera, Bertrand Dousset, more

Annals of Diagnostic Pathology > 2010 > 14 > 1 > 56-59

A 39-year-old woman presented with an incidentally discovered mass of the left adrenal fossa. Computed tomography and magnetic resonance imaging did not show any other lesion. Histologically, this mass was composed of a dense proliferation of spindle cells with a fibrosarcomatous-like pattern. Immunohistochemistry using anticytokeratin showed some epithelial cells within the tumor. The diagnosis of...

article

Exploration biologique de la fonction corticotrope

Yvonne Fulla, Laurence Guignat, Marie-Annick Dugué, Guillaume Assié, more

Revue Francophone des Laboratoires > 2009 > 2009 > 416 > 35-48

La principale hormone glucocorticoïde est le cortisol produit par la corticosurrénale sous l’action stimulante de l’hormone corticotrope hypophysaire (ACTH), elle-même sous la dépendance des peptides hypothalamiques, la corticolibérine (CRH) et dans une moindre mesure la vasopressine. Le cortisol exerce un rétrocontrôle négatif sur la synthèse et la sécrétion des hormones hypothalamo-hypophysaires...

article

Cushing's disease

Xavier Bertagna, Laurence Guignat, Lionel Groussin, Jérôme Bertherat

Best Practice & Research Clinical Endocrinology & Metabolism > 2009 > 23 > 5 > 607-623

Cushing's syndrome refers to the clinical manifestations induced by chronic exposure to excess glucocorticoids. There are three pathological conditions that can result in the chronic overproduction of endogenous cortisol in man: the most frequent is Cushing's disease where adrenocorticotropic hormone (ACTH) is overproduced by a pituitary corticotroph adenoma, rarely ACTH can be produced in an ‘ectopic’...

article

Pathogenesis of adrenocortical cancer

Jérôme Bertherat, Xavier Bertagna

Best Practice & Research Clinical Endocrinology & Metabolism > 2009 > 23 > 2 > 261-271

The study of the clonality of adrenocortical tumours (ACTs) has shown that adrenocortical cancers (ACCs) are of monoclonal origin. Numerous chromosomal alterations have been observed in ACCs, and they are much more frequent than in adrenocortical adenomas. Progress in the genetics of familial syndromes associated with ACTs helped to identify significant somatic molecular alterations in sporadic adult...

article

La parathormone : apport dans la stratégie diagnostique et thérapeutique de l’hyperparathyroïdie primaire

Yvonne Fulla, Xavier Bertagna, Thierry Delbot, Didier Borderie, more

Revue Francophone des Laboratoires > 2009 > 2009 > 411 > 45-56

La définition de l’hyperparathyroïdie primaire (HPT1) est une hypersécrétion de PTH inadaptée à la calcémie et son diagnostic est biologique reposant sur un dosage plasmatique concomitant de PTH et de calcium. L’apport de la biologie dans l’HPT1 est primordial au niveau diagnostic, en bilan de base ou en test dynamique sous charge calcique pour les cas limites à PTH et/ou calcium plasmatiques subnormaux,...

article

Heterogeneity of skin manifestations in patients with Carney complex

Christine Mateus, André Palangié, Nathalie Franck, Lionel Groussin, more

Journal of the American Academy of Dermatology > 2008 > 59 > 5 > 801-810

Carney complex is an autosomal dominant endocrine disorder associated with skin involvement.To describe the dermatological signs of patients diagnosed with Carney complex (CNC) or primary pigmented adrenocortical nodular disease (PPNAD).We conducted a prospective, single-center descriptive study of inpatients and outpatients at a university hospital endocrinology department. Sixteen patients from...

article

Inter- and intra-observer variability in detection and progression assessment with MRI of microadenoma in Cushing’s disease patients followed up after bilateral adrenalectomy

Hélène Bahurel-Barrera, Guillaume Assie, Stéphane Silvera, Xavier Bertagna, more

Pituitary > 2008 > 11 > 3 > 263-269

Objective To assess the inter- and intra-observer variability in detection and progression assessment with MRI of pituitary microadenomas in cases of Cushing’s disease treated by adrenalectomy. Design and Methods Two radiologists independently reviewed initial and follow-up MRI studies of 32 patients with a history of Cushing’s disease on two occasions each. Five classical qualitative signs and three...

article

Reduced Myocardial Contractility Assessed by Tissue Doppler Echocardiography Is Associated with Increased Risk During Adrenal Surgery of Patients with Pheochromocytoma: Report of a Preliminary Study

Christophe Meune, Jérôme Bertherat, Bertrand Dousset, Nicole Jude, more

Journal of the American Society of Echocardiography > 2006 > 19 > 12 > 1466-1470

Depressed myocardial contractility, although rarely reported in pheochromocytoma, might be underestimated. It may be a determinant of perioperative risk during adrenal surgery.We prospectively studied consecutive patients with pheochromocytoma; myocardial function examined by standard and tissue Doppler echocardiography was compared with matched control subjects. The incidence of hemodynamic collapse...

article

Cushing's syndrome

John Newell-Price, Xavier Bertagna, Ashley B Grossman, Lynnette K Nieman

The Lancet > 2006 > 367 > 9522 > 1605-1617

Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.

article

The Nelson's syndrome... revisited

Guillaume Assié, Hélène Bahurel, Jérôme Bertherat, Michèle Kujas, more

Pituitary > 2004 > 7 > 4 > 209-215

Adrenalectomy is a radical therapeutic approach to control hypercortisolism in some patients with Cushing's disease. However it may be complicated by the Nelson's syndrome, defined by the association of a pituitary macroadenoma and high ACTH secretion after adrenalectomy. This definition has not changed since the end of the fifties. Today the Nelson's syndrome must be revisited with new to criteria...

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INFONA - science communication portal

Search results for: Xavier Bertagna

Comment on: “Levothyrox^® New and Old Formulations: Are they Switchable for Millions of Patients?”

Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease

Revisiting the Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease

The ENS@T Initiative

Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing’s disease

Rasch analysis for assessing unidimensionality and identifying measurement biases of malignancy scores in oncology. The example of the Weiss histopathological system for the diagnosis of adrenocortical cancer

Bronchial Carcinoid Tumors Causing Cushing's Syndrome: More Aggressive Behavior and the Need for Early Diagnosis

Preface

The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses

Mutations and polymorphisms in the gene encoding regulatory subunit type 1‐alpha of protein kinase A (PRKAR1A): an update

Unexpected diagnosis for an adrenal tumor: synovial sarcoma

Exploration biologique de la fonction corticotrope

Cushing's disease

Pathogenesis of adrenocortical cancer

La parathormone : apport dans la stratégie diagnostique et thérapeutique de l’hyperparathyroïdie primaire

Heterogeneity of skin manifestations in patients with Carney complex

Inter- and intra-observer variability in detection and progression assessment with MRI of microadenoma in Cushing’s disease patients followed up after bilateral adrenalectomy

Reduced Myocardial Contractility Assessed by Tissue Doppler Echocardiography Is Associated with Increased Risk During Adrenal Surgery of Patients with Pheochromocytoma: Report of a Preliminary Study

Cushing's syndrome

The Nelson's syndrome... revisited

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