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A new series of compounds, namely 2-{[4'-(3''-aryl)-2''-propene-1''-one-phenyl]amino}benzoic acids (3a-3j) and 2-{[4'-(5''-aryl)isoxazol-3''-yl]phenyl amino} benzoic acids (4a-4j), were synthesized. The structures of these compounds were confirmed by 1H NMR, IR, Mass spectral analysis. The compounds (3a-3j) and (4a-4j) have been evaluated their antimicrobial activity.
The Thiosemicarboximide derivatives of (5a-5j) were synthesized by the condensation of Chalcone derivatives (4a-4j) with H2N-NH-CS-NH2 in the presence of glacial acetic acid. The structures of newly synthesized compounds were confirmed based on 1H-NMR, mass spectra, and IR data. All the newly synthesized compounds were screened for their antibacterial activity against Gram +ve Bacteria Bacillus subtilis,...
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