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A new series of 1,3,4-oxadiazole derivatives were prepared from the condensation of acid hydrazide,5-bromo-2-(trifluoromethoxy)benzoic acid in POCl3 by ultrasonic irradiation method. The new synthetic method furnished the desired products in shorter time and good yields. The chemical structures of compounds 4a-h were confirmed by Fourier transform infrared spectroscopy (IR), proton nuclear magnetic...