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Cilia and flagella are beating rod‐like organelles that enable the directional movement of microorganisms in fluids and fluid transport along the surface of biological organisms or inside organs. The molecular motor axonemal dynein drives their beating by interacting with microtubules. Constructing synthetic beating systems with axonemal dynein capable of mimicking ciliary beating still represents...
Adenosine triphosphate (ATP) is the energy source for various biochemical processes and biomolecular motors in living things. Development of ATP antagonists and their stimuli‐controlled actions offer a novel approach to regulate biological processes. Herein, we developed azobenzene‐based photoswitchable ATP antagonists for controlling the activity of motor proteins; cytoplasmic and axonemal dyneins...
Dynein, which is a minus‐end‐directed microtubule motor, is crucial to a range of cellular processes. The mass of its motor domain is about 10 times that of kinesin, the other microtubule motor. Its large size and the difficulty of expressing and purifying mutants have hampered progress in dynein research. Recently, however, electron microscopy, X‐ray crystallography and single‐molecule nanometry...
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