Search results for: Xi Wang

Items from 1 to 20 out of 1,833 results

article

Synthesis of Diaryl Sulfides by Using Tetramethylthiuram Monosulfide (TMTM) as Organosulfur Source: A Practical C(sp²)−S Bond Construction

Xi Wang, Jin‐Quan Chen, Xing‐Xing Yang, Er‐Jun Hao, more

European Journal of Organic Chemistry > 2022 > 18 > n/a - n/a

A protocol for synthesizing symmetrical thioethers by using a cheap organosulfur reagent (tetramethylthiuram monosulfide: TMTM) was developed. Both iodobenzenes and phenylboronic acids react well with TMTM, giving the target products with good to excellent yields. This method features simple performance, wide functional group tolerance, and good to excellent yields, showing a potential application...

article

Retrospective comparative effectiveness research: Will changing the analytical methods change the results?

Nicholas G. Zaorsky, Xi Wang, Eric J. Lehrer, Leila T. Tchelebi, more

International Journal of Cancer > 150 > 12 > 1933 - 1940

In medicine, retrospective cohort studies are used to compare treatments to one another. We hypothesize that the outcomes of retrospective comparative effectiveness research studies can be heavily influenced by biostatistical analytic choices, thereby leading to inconsistent conclusions. We selected a clinical scenario currently under investigation: survival in metastatic prostate, breast or lung...

article

High prevalence of hypertension and target organ damage in patients with 11β‐hydroxylase deficiency

Bang Sun, Lin Lu, Yinjie Gao, Bingqing Yu, more

Clinical Endocrinology > 96 > 5 > 657 - 665

Background Prevalence of hypertension and hypertension‐mediated organ damage (HMOD) had not been well studied in patients with 11β‐hydroxylase deficiency (11β‐OHD). Objective The study was to assess the prevalence and risk factors of hypertension and HMOD in patients with 11β‐OHD. Design Retrospective cohort analysis in a single medical centre. Patients Twenty‐eight patients with 11β‐OHD were...

article

Mixed Monetary–Fiscal Policies and Macroeconomic Fluctuations: An Analysis Based on the Dynamic Stochastic General Equilibrium Model

Xi Wang, Jiayang Li, Guangbin Zhang

China & World Economy > 30 > 2 > 167 - 196

The existing literature on macroeconomic policy research is mainly concerned with the impact of a single monetary or fiscal policy on China's macroeconomic fluctuations in a closed economy. However, the effect of a mix of monetary and fiscal policies has been neglected. This paper addresses this issue with an open economy dynamic stochastic general equilibrium model. It applies impulse‐response and...

article

Synthetic Antibody‐Rhamnose Cluster Conjugates Show Potent Complement‐Dependent Cell Killing by Recruiting Natural Antibodies

Chong Ou, Sunaina Kiran Prabhu, Xiao Zhang, Guanghui Zong, more

Chemistry – A European Journal > 28 > 16 > n/a - n/a

Monoclonal antibodies (mAbs) are one of the most rapidly growing drug classes used for the treatment of cancer, infectious and autoimmune diseases. Complement‐dependent cytotoxicity (CDC) is one of the effector functions for antibodies to deplete target cells. We report here an efficient chemoenzymatic synthesis of structurally well‐defined conjugates of a monoclonal antibody with a rhamnose‐ and...

article

Citronellal alleviates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and apoptosis via Na⁺/H⁺ exchanger‐1 inhibition

Xu Liu, Yue Qiu, Ning Huang, Yan‐hua Liu, more

Journal of Biochemical and Molecular Toxicology > 36 > 3 > n/a - n/a

The medical usage of Doxorubicin (DOX) as a chemotherapeutic agent is restricted owing to its cardiotoxic properties. This study was designed to explore the effect and underlying mechanisms of Citronellal (CT) on DOX‐related cardiotoxicity in rats. Rats were divided into six groups: control, DOX, CT, Lithium chloride (LiCl) (a Na+/H+exchanger‐1 [NHE1] activator), DOX + CT, and DOX + CT + LiCl. To...

article

Ultrathin and Super Strong UHMWPE Supported Composite Anion Exchange Membranes with Outstanding Fuel Cells Performance

Wei Yuan, Lingping Zeng, Ying Li, Jianchuan Wang, more

Small > 18 > 10 > n/a - n/a

For high‐performance anion exchange membrane fuel cells (AEMFCs), the anion exchange membrane (AEMs) should be as thin as possible to reduce the ohmic resistance. However, the mechanical stability of ultrathin AEMs cannot be guaranteed, as well as a huge risk of gas (H₂&O₂) permeation. In this work, composite AEMs based on ultrahigh molecular weight polyethylene (UHMWPE) are prepared by in situ...

article

A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

Wanjun Liu, James A. Flanders, Long‐Hai Wang, Qingsheng Liu, more

Small > 18 > 8 > n/a - n/a

Encapsulation and transplantation of insulin‐producing cells offer a promising curative treatment for type 1 diabetes (T1D) without immunosuppression. However, biomaterials used to encapsulate cells often elicit foreign body responses, leading to cellular overgrowth and deposition of fibrotic tissue, which in turn diminishes mass transfer to and from transplanted cells. Meanwhile, the encapsulation...

article

Interobserver agreement in the diagnosis of anal dysplasia: comparison between gastrointestinal and gynaecological pathologists and utility of consensus conferences

Sohaib Abu‐Farsakh, Michael G Drage, Aaron R Huber, Bradley M Turner, more

Histopathology > 80 > 4 > 648 - 655

Aims Management of anal dysplasia relies upon the accurate diagnosis of anal biopsy specimens. As institutions move towards subspecialty signout (SSSO), decisions must be made regarding whether to assign anal biopsies to the gastrointestinal (GI) or gynaecological (GYN) pathology service. Materials and results We identified 200 archival tissue biopsies of anal mucosa and circulated them among three...

article

Tbx18 promoted the conversion of human‐induced pluripotent stem cell‐derived cardiomyocytes into sinoatrial node‐like pacemaker cells

Wei Zhang, Hongyi Zhao, Dajun Quan, Yanhong Tang, more

Cell Biology International > 46 > 3 > 403 - 414

Sinoatrial node (SAN) pacemaker cells originate from T‐box transcription factor 18 (Tbx18)‐expressing progenitor cells. The present study aimed to investigate whether overexpression of human transcription factor Tbx18 could reprogram human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) into SAN‐like pacemaker cells (SANLPCs) in vitro. In the study, hiPSCs were first differentiated...

article

Urban spatial epidemic simulation model: A case study of the second COVID‐19 outbreak in Beijing, China

Qiang Huang, Qiyong Liu, Ci Song, Xiaobo Liu, more

Transactions in GIS > 26 > 1 > 297 - 316

The second COVID‐19 outbreak in Beijing was controlled by non‐pharmaceutical interventions, which avoided a second pandemic. Until mass vaccination achieves herd immunity, cities are at risk of similar outbreaks. It is vital to quantify and simulate Beijing's non‐pharmaceutical interventions to find effective intervention policies for the second outbreak. Few models have achieved accurate intra‐city...

article

A 10‐MHz to 50‐GHz low‐jitter multiphase clock generator for high‐speed oscilloscope in 0.15‐μm GaAs technology

Tianxiang Wu, Xi Wang, Yong Chen, Junyan Ren, more

International Journal of Circuit Theory and Applications > 50 > 2 > 367 - 381

The data acquisition system is widely used in electronic measuring instruments, for example, the oscilloscope. The development direction of the oscilloscope reflects the research status and development trend of the data acquisition system. Currently, the index of oscilloscopes is progressing toward a high sampling rate, and the performance of the analog‐to‐digital converter (ADC) has become the main...

article

The Impact of Ion Migration on the Electro‐Optic Effect in Hybrid Organic–Inorganic Perovskites

Meng‐Jia Sun, Randy Sabatini, Pei‐Xi Wang, Amin Morteza Najarian, more

Advanced Functional Materials > 32 > 4 > n/a - n/a

Electro‐optic (EO) modulation allows the conversion of electrical signals to optical pulses and is widely employed in telecommunications and chip‐to‐chip interconnects. Recently, hybrid organic–inorganic perovskites (HOIPs) have been explored as candidates for EO modulators. To improve the EO performance, it is envisioned that halide doping will lower the symmetry of the crystal, enhancing spontaneous...

article

Associations between electronic devices use and common mental traits: A gene–environment interaction model using the UK Biobank data

Jing Ye, Shiqiang Cheng, Xiaomeng Chu, Yan Wen, more

Addiction Biology > 27 > 2 > n/a - n/a

Background Electronic devices use has been reported to be associated with depression. However, limited effort has been provided to elucidate the associations between electronic devices use and mental traits in interaction with genetic factors. Methods We first conducted an observational study consisting of 138 976–383 742 participants for TV watching, 29 636–38 599 participants for computer using...

article

Association between plasma free fatty acid levels and primary angle‐closure glaucoma based on a mass spectrometry metabolomics analysis

Yuting Qin, Xiaofei Feng, Huihuan Luo, Shengqiang Liu, more

Acta Ophthalmologica > 100 > 1 > e204 - e212

Purpose To determine the association between plasma free fatty acid (FFA) levels and primary angle‐closure glaucoma (PACG). Methods Free fatty acid (FFA) levels in patients with PACG (n = 181) and people without glaucoma (n = 340) were compared. Twenty‐two FFAs and six lipid classes were measured using metabolomics analysis. Odds ratio (OR) of these metabolites and their 95% confidence intervals...

article

The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway

Huan Liu, Cuiyan Wu, Hongmou Zhao, Feng’e Zhang, more

The FEBS Journal > 289 > 1 > 279 - 293

Kashin–Beck disease (KBD) is an endemic osteochondropathy. Due to a lack of suitable animal or cellular disease models, the research progress on KBD has been limited. Our goal was to establish the first disease‐specific human induced pluripotent stem cell (hiPSC) cellular disease model of KBD, and to explore its etiology and pathogenesis exploiting transcriptome sequencing. HiPSCs were reprogrammed...

article

Unraveling Strain Gradient Induced Electromechanical Coupling in Twisted Double Bilayer Graphene Moiré Superlattices

Yuhao Li, Xiao Wang, Deqi Tang, Xi Wang, more

Advanced Materials > 33 > 51 > n/a - n/a

Moiré superlattices of 2D materials with a small twist angle are thought to exhibit appreciable flexoelectric effect, though unambiguous confirmation of their flexoelectricity is challenging due to artifacts associated with commonly used piezoresponse force microscopy (PFM). For example, unexpectedly small phase contrast (≈8°) between opposite flexoelectric polarizations is reported in twisted bilayer...

article

Preparation of casein phosphopeptides calcium complex and the promotion in calcium cellular uptake through transcellular transport pathway

Haizhi Li, Shenglin Duan, Peng Yuan, Jia Liu, more

Journal of Food Biochemistry > 45 > 12 > n/a - n/a

This study evaluated the stability of casein phosphopeptides (CPP) and obtained peptide–calcium complex by heating and chelating the peptide with CaCl₂ in a neutral solution. To assess the bioavailability of various calcium formulations, the calcium transport models were established in Caco‐2 cells, and the transcellular transport pathways of various calcium formulations were studied by RT‐PCR and...

article

The interplay of protein engineering and glycoengineering to fine‐tune antibody glycosylation and its impact on effector functions

Qiong Wang, Tiexin Wang, Roushu Zhang, Shuang Yang, more

Biotechnology and Bioengineering > 119 > 1 > 102 - 117

The N‐glycan pattern of an IgG antibody, attached at a conserved site within the fragment crystallizable (Fc) region, is a critical antibody quality attribute whose structural variability can also impact antibody function. For tailoring the Fc glycoprofile, glycoengineering in cell lines as well as Fc amino acid mutations have been applied. Multiple glycoengineered Chinese hamster ovary cell lines...

article

Textile Waste Fiber Regeneration via a Green Chemistry Approach: A Molecular Strategy for Sustainable Fashion

Xuantong Sun, Xi Wang, Fengqiang Sun, Mingwei Tian, more

Advanced Materials > 33 > 48 > n/a - n/a

Fast fashion, as a continuously growing part of the textile industry, is widely criticized for its excessive resource use and high generation of textiles. To reduce its environmental impacts, numerous efforts are focused on finding sustainable and eco‐friendly approaches to textile recycling. However, waste textiles and fibers are still mainly disposed of in landfills or by incineration after their...

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INFONA - science communication portal

Search results for: Xi Wang

Synthesis of Diaryl Sulfides by Using Tetramethylthiuram Monosulfide (TMTM) as Organosulfur Source: A Practical C(sp²)−S Bond Construction

Retrospective comparative effectiveness research: Will changing the analytical methods change the results?

High prevalence of hypertension and target organ damage in patients with 11β‐hydroxylase deficiency

Mixed Monetary–Fiscal Policies and Macroeconomic Fluctuations: An Analysis Based on the Dynamic Stochastic General Equilibrium Model

Synthetic Antibody‐Rhamnose Cluster Conjugates Show Potent Complement‐Dependent Cell Killing by Recruiting Natural Antibodies

Citronellal alleviates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and apoptosis via Na⁺/H⁺ exchanger‐1 inhibition

Ultrathin and Super Strong UHMWPE Supported Composite Anion Exchange Membranes with Outstanding Fuel Cells Performance

A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

Interobserver agreement in the diagnosis of anal dysplasia: comparison between gastrointestinal and gynaecological pathologists and utility of consensus conferences

Tbx18 promoted the conversion of human‐induced pluripotent stem cell‐derived cardiomyocytes into sinoatrial node‐like pacemaker cells

Urban spatial epidemic simulation model: A case study of the second COVID‐19 outbreak in Beijing, China

A 10‐MHz to 50‐GHz low‐jitter multiphase clock generator for high‐speed oscilloscope in 0.15‐μm GaAs technology

The Impact of Ion Migration on the Electro‐Optic Effect in Hybrid Organic–Inorganic Perovskites

Associations between electronic devices use and common mental traits: A gene–environment interaction model using the UK Biobank data

Association between plasma free fatty acid levels and primary angle‐closure glaucoma based on a mass spectrometry metabolomics analysis

The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway

Unraveling Strain Gradient Induced Electromechanical Coupling in Twisted Double Bilayer Graphene Moiré Superlattices

Preparation of casein phosphopeptides calcium complex and the promotion in calcium cellular uptake through transcellular transport pathway

The interplay of protein engineering and glycoengineering to fine‐tune antibody glycosylation and its impact on effector functions

Textile Waste Fiber Regeneration via a Green Chemistry Approach: A Molecular Strategy for Sustainable Fashion

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