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Parameters derived from the acoustic backscatter coefficient (BSC) represent quantification on an absolute scale and have been used to characterize tissue microstructure. This motivates their use to detect and quantify microstructural remodeling and ripening of the uterine cervix during pregnancy. This work systematically assessed the ex vivo human cervix microstructure and the effects of cervical...
We are investigating backscatter-based quantitative ultrasound parameters to detect premature cervical remodeling ultimately leading to spontaneous preterm birth. This work systematically assesses the ex vivo human cervix microstructure and the effects of cervical ripening based on parameters derived from the acoustic backscatter coefficients (BSCs).
The non-pregnant cervix is composed of layers of pseudo-aligned collagen wrapped circumferentially around the cervical canal. Studies in rodents have shown that this structure disorganizes and breaks down throughout normal pregnancy. There is evidence to suggest that layered, pseudo-aligned collagen fibers in the non-pregnant cervix induce an angle-dependence (anisotropy) in backscattered ultrasound...
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