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(S)-3-chloro-1-phenyl-1-propanol ((S)-CPPO) is an important chiral intermediate predominantly used in the synthesis of the chiral side chain of (S)-fluoxetine. In this study, carbonyl reductase (CBR) from Novosphingobium aromaticivorans was successfully expressed in recombinant E. coli. The enzymatic activity of the recombinant CBR was significantly increased to 1875 U/mL in the fed-batch fermentation...
Confocal fundamental and harmonic superimposition can greatly lower the cavitation threshold and enhance cavitation activity via wave interference. In this study, a histotripsy protocol of using dual frequency of fundamental and harmonic superimposition combined with hundred-microsecond-length pulses and two stages is proposed and testified to get good use of the nonlinear regimes of enhanced cavitation...
Histotripsy is a new non-invasive therapy modality and can mechanically disintegrating target tissue for tumor treatment. In this study, we propose a strategy of dual frequency of fundamental and harmonic superimposition combined with hundred-microsecond-length pulses and two stages to get good use of the nonlinear regimes of enhanced cavitation and boiling. Confocal fundamental and harmonic superimposition...
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