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Electromagnetic field and treatment systems are one of the important research subjects of today. In this project, antenna and coil designs and analyzes were performed for different types of DMAT treatment systems. Electromagnetic field exposure, besides power density and distance; It is determined by physical properties such as the duration of exposure, type (near or far field), frequency of the source,...
In the scope of bone tissue engineering, there has still been great amount of demand on synthetic bone graft that induces differentiation of osteoprogenitor cells by cell-matrix interaction at the nanoscale as well as mimicking micro assembly of compact bone while providing high mechanical strength. In this study, we aimed to develop synthetic bone grafts based on beta-tricalcium phosphate (β-TCP)...
In the late years, a dramatic increase in the number of commercial products has emerged in recent introduction of first injectable bone grafts. Bone substitutes developed as highly water retained hydrogel structures and calcium phosphate based ceramic composites have gained popularity especially in orthopedics and maxillofacial applications. These injectable bone grafts support bone tissue, which...
Continuation of vitalization of organs and tissues is an important step for rejection of implanted tissue. HUVEC (Human Umbilicial Vein Endothelial Cells) are endothelial derived cells. One of the model cell types that plays an effective role in the vascularization process and it is also widely used in terms of 3D (dimensional) tissue formation. The 3D tissue vascularization process appears to be...
Polymers and hydrogels are used to create 3D tissue scaffolds. The hydrogel solutions that are formed using PEGDMA polymer were tried to be given antimicrobial effect by applying cold atmospheric plasma. In addition, L929 cells were encapsulated and cell viability was checked.
Electrospinning is a bio-fabrication method, which helps to produce highly interconnected nano-porous structure with a high surface to volume ratio by using polymer solutions. In tissue engineering applications, scaffolds composed of electrospun nanofibers are produced from synthetic polymers to resemble specific tissue. Most of synthetic polymers has high hydrophobicity since the nonpolar groups...
Vascular scaffolds produced by bio-fabrication methods can provide ideal conditions for attachment and proliferation of ECs (endothelial cells). But these grafts might not allow migration of cells into the scaffold. Therefore, scaffolds, which resembles ECMs (extracellular matrix) should produce by changing scaffold size and shape. The diameter of nanofibers can be controlled by using electrospinning...
Pulsed Electromagnetic Fields (PEMFs), are usually low-frequency fields with very specific wave shapes and amplitude, have been shown to accelerate wound healing and are used in adjuvant therapy. Also Pulsed Radio Frequency Energy (PRFE) is another term for this therapy that delivers electromagnetic signals to a target tissue without the intended generation of deep heat. Although the exact mechanism...
In scientific area, many different studies are carried out to ensure the development of more effective and rapid wound healing method. Applied and developed several methods aims rapid wound healing with minimal discomfort to the patient which is also allow the movement of epithelial cells and to allow the regeneration of cells during to wound healing process with provided the ideal environment. It...
Besides the material type, surface characteristics of titanium based dental implants also affect the treatment success and time. Atmospheric Cold Plasma (ACP) treatment and RGD peptide conjugation methods are applied to titanium implants for shortening the osseointegration time by increasing the surface hydrophilicty and cell adhesion rate. However the comparative effect of these two implant surface...
In this study, the custom design of this bioprinter was designed by using the 3D printing technology and it was tested to print biotechnological samples, which made up of hydrogel (PEGDA) single layer with different shapes and sizes. The custom designed printer is fully controlled by computer programming, that allows printing in accurate way and make our target closed to be fulfilled to print, in...
In the scope of bone tissue engineering, there has still been great amount of demand on designing biomimetic scaffolds that induces differentiation of osteoprogenitor cells by cell-matrix interaction at the nanoscale as well as mimicking micro assembly of compact bone while providing high mechanical strength. In this study, in order to use in the treatment of large bone defects, osteon mimetic 3D...
Clinic applications of bone tissue (BT) transplantation are used widely for treatment of large bone defects. In BT field, development of biomimetic bone tissue scaffolds which have appropriate chemical and mechanical properties for clinic applications is needed. Biomimetic bone tissue scaffolds should be used for bone grafts which are developed with tissue engineering approach to mimic extracellular...
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