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The aim of this study was to investigate the synergistic effect of cold atmospheric plasma (CAP) treatment and RGD peptide coating for enhancing cellular attachment and proliferation over titanium (Ti) surfaces. The surface structure of CAP-treated and RGD peptide-coated Ti discs were characterized by contact angle goniometer and atomic force microscopy. The effect of such surface modification on...
In the scope of bone tissue engineering, there has still been great amount of demand on synthetic bone graft that induces differentiation of osteoprogenitor cells by cell-matrix interaction at the nanoscale as well as mimicking micro assembly of compact bone while providing high mechanical strength. In this study, we aimed to develop synthetic bone grafts based on beta-tricalcium phosphate (β-TCP)...
In the late years, a dramatic increase in the number of commercial products has emerged in recent introduction of first injectable bone grafts. Bone substitutes developed as highly water retained hydrogel structures and calcium phosphate based ceramic composites have gained popularity especially in orthopedics and maxillofacial applications. These injectable bone grafts support bone tissue, which...
Pulsed Electromagnetic Fields (PEMFs), are usually low-frequency fields with very specific wave shapes and amplitude, have been shown to accelerate wound healing and are used in adjuvant therapy. Also Pulsed Radio Frequency Energy (PRFE) is another term for this therapy that delivers electromagnetic signals to a target tissue without the intended generation of deep heat. Although the exact mechanism...
In scientific area, many different studies are carried out to ensure the development of more effective and rapid wound healing method. Applied and developed several methods aims rapid wound healing with minimal discomfort to the patient which is also allow the movement of epithelial cells and to allow the regeneration of cells during to wound healing process with provided the ideal environment. It...
Besides the material type, surface characteristics of titanium based dental implants also affect the treatment success and time. Atmospheric Cold Plasma (ACP) treatment and RGD peptide conjugation methods are applied to titanium implants for shortening the osseointegration time by increasing the surface hydrophilicty and cell adhesion rate. However the comparative effect of these two implant surface...
In the scope of bone tissue engineering, there has still been great amount of demand on designing biomimetic scaffolds that induces differentiation of osteoprogenitor cells by cell-matrix interaction at the nanoscale as well as mimicking micro assembly of compact bone while providing high mechanical strength. In this study, in order to use in the treatment of large bone defects, osteon mimetic 3D...
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