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Malaria remains one of the most important public health concerns worldwide. It causes nearly half a million deaths every year, and about 40% of the world's population lives in the endemic regions of malaria. A major hurdle in antimalarial development is our limited understanding of the dynamic cellular networks in the malaria parasite. In this study, by coupling RNA-Seq analysis and network mining...
Malaria is one of the most deadly infectious diseases in the world. The malaria burden is characterized by 207 million cases and over 627,000 deaths annually. The consistent morbidity and mortality underscore an urgent need for the development of next-generation antimalarials. In this paper, we propose a network mining approach to uncover the protein-protein associations that are implicated in important...
Malaria is a serious infectious disease that affects 300–500 million people in the world. The proteins involved in heat shock response in the malaria parasite Plasmodium falciparum have long been considered as promising vaccine and drug targets. Our comprehensive network analysis reveals that about 103 heat shock proteins are associated with over 900 other proteins. They may play roles in a wide variety...
Species of the family Vibrionaceae are ubiquitous in marine environments and the family contains numerous important pathogens of humans and marine species. In order to find the core, accessory and pan-proteome of this family, we deduced the complete set of orthologs for eleven strains from this family. The core proteome consists of 1,882 groups of orthologs, which is 28% of the 6,629 orthologous groups...
Plasmodium falciparum, the causative agent of human malaria, has a dynamic life cycle encompassing the mosquito vector and human hosts. Complex and atypical cell cycles are observed in malaria parasites. Cell cycle related proteins which play important roles in parasite life cycle, but distantly related to host proteins, may serve as desirable drug targets. In this study, based on the principle of...
Proteases play diverse and important roles in metabolic regulation, gene regulatory networks and protein-protein interactions. The complete sequencing of the genomes of three unicellular organisms: malaria parasite Plasmodium falciparum, and the two free-living ciliates Tetrahymena thermophila and Paramecium tetraurelia has opened a new window to study the proteolytic machinery in a large scale systems...
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