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We presented a multi-scale model, by coupling of three different component models: individual based model (IBM), spatial moment-based model (SMBM) and equation-based model (EBM), for studying of spreading of infectious disease in a 3D office building. We proposed an up-scaling methodology to derive a SMBM from a given IBM, and to generate an EBM from the SMBM. Our results showed that the multi-scale...