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In the present study, we investigated the effect of ERK1/2 and JNK signaling pathway in the inhibition of AcSDKP on the proliferation and collagen synthesis in cultured rat cardiac fibroblasts induced by PDGF. By using MTT assay and Western Blot analysis, we found that treating the fibroblasts with PDGF, phospho-ERK1/2 and phospho-JNK expression was significantly increased compared with the control...
Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis. Our recent studies have shown that AcSDKP has a anti-fibrotic effect in the lung of rats with silicosis. Here we explore the underlying effect of AcSDKP on myofibroblast differentiation during the anti-fibrotic process. SiO2 powders were instilled in trachea of rat to make...
We previously reported that tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) inhibited pulmonary inflammation and fibrosis in SiO 2 -induced silicosis. This study aimed to explore the precise mechanism involved.Rats were divided into 3 groups: 1) sham (saline), 2) silicosis+vehicle, and 3) silicosis+Ac-SDKP [800μg/(kgd)]. SiO 2 particles or saline were administered by tracheal...
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