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We present an algorithm, Sparse Atomic Feature Learning (SAFL), that transforms noisy labeled datasets into a sparse domain by learning atomic features of the underlying signal space via gradient minimization. The sparse signal representations are highly compressed and cleaner than the original signals. We demonstrate the effectiveness of our techniques on fMRI activity patterns. We produce low-dimensional,...
This study tested the hypothesis that diffusion tensor imaging can detect alteration in microscopic integrity of white matter and basal ganglia regions known to be involved in Parkinson's disease (PD) pathology. It was also hypothesized that there is an association between diffusion abnormality and PD severity and subtype. Diffusion tensor imaging at 4 Tesla was obtained in 12 PD and 20 control subjects,...
Looping and cleavage of single DNA molecules by the two-site restriction endonuclease Sau3AI were measured with optical tweezers. A DNA template containing many recognition sites was used, permitting loop sizes from ∼10 to 10,000 basepairs. At high enzyme concentration, cleavage events were detected within 5s and nearly all molecules were cleaved within 5min. Activity decreased ∼10-fold as the DNA...
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