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Effective manipulation and rapid injection of nanosensor with high cell viability have great significance to biological and biomedical applications such as drug delivery and cells biology. This study presents manipulation of a magnetic nanosensor with a temperature indicator and immobilization onto cell surface using glass nanoprobe by Coulomb's force. The nanosensor is stained by Rhodamine B as the...
In the study of the oocytes/embryos, such as enucleation, microinjection in order to increase the success ratio of the fertilization and characteristics study of the oocytes, all of these research and clinical applications involve 3-D rotation of mammalian oocytes. The gesture or the orientation of the oocyte is critical for improving the enucleation success rate, and characteristics investigation...
For molecular analysis of the rare cells, such as Circulating Tumor Cells (CTCs), the rare cells isolation from the suspension which contains large population of other cells on the single cells level is required. In this paper, we fabricated and demonstrated a cell isolation system for rare CTCs. We utilized the technique of convective self-assembly, which is a technique for depositing uniform onto...
Bio-actuated, especially flagellated bacteria-driven, micro/nanorobots have been actively studied to develop novel technologies such as drug delivery systems (DDS), though the characteristics of the actuator (flagellar motor) have not been sufficiently investigated. For analysis or control of the bacterial flagellar motor, we previously proposed the local environmental control system with nano/micro...
In this research, we demonstrated a microfluidic chip to pretreat the samples for viral genome assay. The microfluidic chip has the following three functions; (1) Virus purification and enrichment, (2) Viral RNA extraction, and (3) Capture of the targeted virus genome. Hydroxyapatite chromatography, Boom method, and PNA (Peptide Nucleic Acid) were used for the above three functions, respectively....
We have succeeded in protein crystallization and processing by electrically-induced bubble knife. The dispensed directional mono-dispersed micro-bubbles whose air-liquid interface tends to combine the ambient molecules due to by their stiction force on the surface of micro-bubbles. Electrically-induced bubble knife enables to generate mono-dispersed micro-bubbles by the electrolysis and local heat,...
We have successfully produced mono-dispersed micro-gas bubbles for less than around 10 µm diameter by micro-bubble knife which produce micro-bubble in an electrically induced ultrasonic field. The discharged output power and conductive area of micro-electrode in micro-bubble knife which cuts the cell by micro-bubble were controlled by glass shell insulation around the copper micro-wire. A small space...
In this paper, we newly propose an organ-explanted bionic simulator (OBiS) using an isolated organ tissue. We use a heart isolated from the chick embryo for proposed simulator. To achieve the OBiS, we perform the concurrent microvascular anastomosis by using suction-induced vascular fixation (SVF) method for easily connection to artificial tubes with blood vessels led to the explanted chick's heart...
In this paper, we propose 3DOF dual-arm microrobots which enabling manipulation and force sensing for a single cell of microorganisms in a microfluidic chip. The untethered microrobots are actuated by permanent magnets which can supply mN order force to stimulate microorganisms and measure the applied force where we want to measure them. The design and fabrication of the untethered microrobots with...
In this paper, we newly propose an on-chip force sensing by using a magnetically driven microtool (MMT) equipped with a frame structure for measurement of stimulant property of Pleurosira laevis. The design and fabrication of the force sensing structure with a displacement magnification mechanism based on beam deformation is discussed. Through the basic experiments, the advantages of the proposed...
We proposed size-dependent microparticle filtration and particle trap by centrifugal force and mechanical restriction using three-dimensional magnetically driven microtool (3D-MMT) in a microfluidic chip. Novelties of this paper are summarized as follows. (1) Filtration of particles is robust against pressure fluctuation in microchannels rather than using only hydrodynamic force because particles...
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