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Telomerases protect the ends of linear chromosomes from shortening. They are composed of an RNA (TLC1 in S. cerevisiae) and several proteins. TLC1 undergoes several maturation steps before it is exported into the cytoplasm to recruit the Est proteins for complete assembly. The mature telomerase is subsequently reimported into the nucleus, where it fulfills its function on telomeres. Here, we show...
In this paper, we present a novel single channel speech enhancement method based on sparse representation and dictionary learning. In the proposed method, noise is distinguished between structured and unstructured. First, the noise dictionary is learned from a training noise database. Then, the structured noise is removed iteratively by using the noise dictionary and iterative formulas. Finally, the...
A novel approach for time-scale modification (TSM) of speech based on temporal continuous nonnegative matrix factorisation (TCNMF) is presented. First, the magnitude spectrum of the speech is factorised to the nonnegative space and the time-varying gains, and then the TSM problem is transformed into an interpolation problem of the timevarying gains, which leads to a better performance over the traditional...
This paper addresses the problem of single channel speech separation using nonnegative matrix factorization (NMF) technique. In general, the standard NMF algorithm by itself does not guarantee statistical relationship between the matrices it computes. This leads to poor separation performance. To solve this problem, we propose to enforce disjointness constraint on the standard NMF algorithm in the...
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