Stephen W. Turner

article

Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing

Seyed Yahya Anvar, Guy Allard, Elizabeth Tseng, Gloria M. Sheynkman, more

Genome Biology > 2018 > 19 > 1 > 1-18

Background The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the interdependence of transcription initiation, splicing and polyadenylation events on single mRNA molecules by full-length mRNA sequencing. Results In MCF-7 breast cancer cells, we find 2700 genes with interdependent alternative...

chapter

Intelligent transportation as the key enabler of smart cities

Stephen W. Turner, Suleyman Uludag

NOMS 2016 - 2016 IEEE/IFIP Network Operations and Management Symposium > 1261 - 1264

NOMS 2016 - 2016 IEEE/IFIP Network Operations and Management Symposium

Smart Cities include the concept of large, intelligent systems coming together cooperatively to enable better living conditions in future urban areas. Reduction in fuel/electricity usage, crime, improved economies, less waste, and overall better living conditions are primary goals. A key enabling technology is the Intelligent Transportation System (ITS), in which various transportation mechanisms...

article

Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications

Thang T. Pham, Jun Yin, John S. Eid, Evan Adams, more

Molecular Genetics and Genomics > 2016 > 291 > 3 > 1491-1504

A gene-level targeted enrichment method for direct detection of epigenetic modifications is described. The approach is demonstrated on the CGG-repeat region of the FMR1 gene, for which large repeat expansions, hitherto refractory to sequencing, are known to cause fragile X syndrome. In addition to achieving a single-locus enrichment of nearly 700,000-fold, the elimination of all amplification steps...

chapter

Towards a flipped cyber classroom to facilitate active learning strategies

Stephen W. Turner, Mark Allison, Zahid Syed, Michael Farmer

2015 IEEE Frontiers in Education Conference (FIE) > 1 - 4

2015 IEEE Frontiers in Education Conference (FIE)

Success within the distance learning paradigm typically requires a strong intrinsic motivation on the part of the learner. This motivation needs to be matched with effective delivery of engaging course content. Developing an active engagement environment for deep learning is a nontrivial task as the instructor is not physically present. To address the concern in an online/blended delivery model, we...

article

Nanopore-Enhanced Positioning of Molecules in Zero-Mode Waveguides

Joseph W. Larkin, Mathieu Foquet, Stephen W. Turner, Jonas Korlach, more

Biophysical Journal > 2015 > 108 > 2 Supplement 1 > 330a

article

Early-life residential exposure to soil components in rural areas and childhood respiratory health and allergy

Graham Devereux, Nara Tagiyeva, Stephen W. Turner, Jon G. Ayres, more

Science of the Total Environment > 2014 > 466-467 > Complete > 338-344

The increase in asthma and allergies has been attributed to declining exposure to environmental microorganisms. The main source of these is soil, the composition of which varies geographically and which is a major component (40–45%) of household dust. Our hypothesis-generating study aimed to investigate associations between soil components, respiratory health and allergy in a Scottish birth cohort...

article

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Sean P. Saunders, Christabelle S.M. Goh, Sara J. Brown, Colin N.A. Palmer, more

The Journal of Allergy and Clinical Immunology > 2013 > 132 > 5 > 1121-1129

Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier deficiency initiating AD came from flaky tail mice, which have a frameshift mutation in Flg and also carry an unknown gene, matted, causing a matted hair phenotype.We sought to identify the matted...

chapter

Student perceptions of cheating in online and traditional classes

Stephen W. Turner, Suleyman Uludag

2013 IEEE Frontiers in Education Conference (FIE) > 1131 - 1137

2013 IEEE Frontiers in Education Conference (FIE)

With classroom instruction undergoing a massive transformation to incorporate online learning techniques at unprecedented levels, technological advances have facilitated a range of mechanisms that improve teaching and learning. At the same time, these technological advances have also facilitated different forms of cheating in classes.

chapter

Assessment of a frugal, virtual and green computing lab infrastructure of the future

Suleyman Uludag, Murat Karakus, Evrim Guler, Stephen W. Turner, more

2012 Frontiers in Education Conference Proceedings > 1 - 6

2012 IEEE Frontiers in Education Conference (FIE)

The impact of the computing field is becoming more profound everyday in all facets of modern society. Despite significant efforts from academia and relatively high demand for computing, technology producers are needed more than ever. This has been corroborated by a recent NSF Press Release [1], stating that computing is the only STEM discipline with more job openings than college graduates to fill...

chapter

Integrated photonic structures for efficient, massively-parallel collection of directional single-molecule fluorescence

Annette Grot, Aaron Rulison, Pei-Lin Hsiung, Janice Cheng, more

2012 International Conference on Optical MEMS and Nanophotonics > 67 - 68

2012 IEEE Photonics Society International Conference on Optical MEMS and Nanophotonics

A conical micromirror is shown to increase the signal from fluorescent molecules within a collocated subwavelength metal aperture by 5×. Large-scale integration (75,000 miromirrors/aperture pairs) is demonstrated.

chapter

Teaching computing and programming fundamentals via App Inventor for Android

Murat Karakus, Suleyman Uludag, Evrim Guler, Stephen W. Turner, more

2012 International Conference on Information Technology Based Higher Education and Training (ITHET) > 1 - 8

2012 11th International Conference on Information Technology Based Higher Education and Training (ITHET)

In this age of growing importance for interdisciplinary studies, the field of computing, and its indispensable component, programming, have become increasingly important not only for STEM areas but also for many other fields. Computational chemistry, bio-informatics, computational linguistics, computational toxicology, etc. are just a few examples of the crossover disciplines that benefit significantly...

chapter

Virtualized lab infrastructure on a budget for various computing and engineering courses

Evrim Guler, Suleyman Uludag, Murat Karakus, Stephen W. Turner

2012 International Conference on Information Technology Based Higher Education and Training (ITHET) > 1 - 7

2012 11th International Conference on Information Technology Based Higher Education and Training (ITHET)

Educators in Science, Technology, Engineering, and Mathematics (STEM) fields, especially in computing and engineering, must be flexible, up-to-date, and able to offer their students practical experience with continually changing information technologies. The importance of practical work in science and engineering, supported by lab exercises, is widely known. While it is desirable to create physical...

article

Going beyond five bases in DNA sequencing

Jonas Korlach, Stephen W Turner

Current Opinion in Structural Biology > 2012 > 22 > 3 > 251-261

DNA sequencing has provided a wealth of information about biological systems, but thus far has focused on the four canonical bases, and 5-methylcytosine through comparison of the genomic DNA sequence to a transformed four-base sequence obtained after treatment with bisulfite. However, numerous other chemical modifications to the nucleotides are known to control fundamental life functions, influence...

article

Regulatory role of IL10 genetic variations in determining allergen-induced TH2 cytokine responses in children

Catherine M. Hayden, Guicheng Zhang, Parveenjeet K. Judge, Siew-Kim Khoo, more

The Journal of Allergy and Clinical Immunology > 2011 > 128 > 1 > 237-239.e8

article

Changes in exhaled nitric oxide after ingestion of L‐arginine in children: A pilot study

Ibrahim Abuzayan, Stephen W. Turner

Pediatric Pulmonology > 45 > 3 > 236 - 240

RationaleExhaled nitric oxide (FE_NO) may be a useful biomarker for asthma and is derived from enzymatic activity on the amino acid L‐arginine. The aim of the present pilot study was to study the effect of L‐arginine ingestion on FE_NO and also NO production in the proximal and distal airways. MethodsAsthmatic and control children were enrolled and phenotyped by skin prick reactivity and spirometry...

chapter

Contention-Free 2D-Mesh Cluster Allocation in Hypercubes

Stephen W. Turner, Lionel M. Ni, Betty H.C. Cheng

1993 International Conference on Parallel Processing - ICPP'93 > 2 > 125 - 129

1993 International Conference on Parallel Processing - ICPP'93

Tkaditionally, each job in a hypercube multiprocessor is allocated with a subcube so that communication interference among jobs may be avoided. Although the hypercube is a powerful processor topology, the 2D mesh is a more popular application topology. This paper predents a 2Dmesh cluster allocation strategy for hypercubes. The proposed auxiliary free list procwor allocation strategy can efficiently...

INFONA - science communication portal

Search results for: Stephen W. Turner

Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing

Intelligent transportation as the key enabler of smart cities

Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications

Towards a flipped cyber classroom to facilitate active learning strategies

Nanopore-Enhanced Positioning of Molecules in Zero-Mode Waveguides

Early-life residential exposure to soil components in rural areas and childhood respiratory health and allergy

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Student perceptions of cheating in online and traditional classes

Assessment of a frugal, virtual and green computing lab infrastructure of the future

Integrated photonic structures for efficient, massively-parallel collection of directional single-molecule fluorescence

Teaching computing and programming fundamentals via App Inventor for Android

Virtualized lab infrastructure on a budget for various computing and engineering courses

Going beyond five bases in DNA sequencing

Regulatory role of IL10 genetic variations in determining allergen-induced TH2 cytokine responses in children

Changes in exhaled nitric oxide after ingestion of L‐arginine in children: A pilot study

Contention-Free 2D-Mesh Cluster Allocation in Hypercubes

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