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The restitution of biological information in the framework of a new discipline, the information design, aims to develop new user-friendly tools for facilitating the comprehension of the medical or biological reality by a polymorphic end-user (patient, physician, or researcher in bioinformatics, biomathematics and life sciences). For that purpose, challenging problems will be presented: i) how to represent...
The biological information coming from electro-physiologic signal sensors like ECG or molecular signal devices like mass spectrometry has to be compressed for an efficient medical use by clinicians or to retain only the pertinent explanatory information about the mechanisms at the origin of the recorded signal for the researchers in life sciences. When the signal is periodic in time and/or space,...
Modelling contagious diseases needs to include a mechanistic knowledge about contacts between hosts and pathogens as specific as possible, e.g., by incorporating in the model information about social networks through which the disease spreads. The unknown part concerning the contact mechanism can be modelled using a stochastic approach. For that purpose, we revisit SIR models by introducing first...
Modelling contagious diseases needs to incorporate in the models information about social networks through which the disease spreads out as well as data about demographic and genetic changes in the susceptible population, and also to include mechanistic knowledge about contacts between hosts and pathogens. We will introduce all these elements in two examples of contagious diseases, the obesity, a...
The paper deals with medical temporal scales based on both the chronologic time of the physician who observes the patient, the proper inner time of the patient (related to the circadian rhythms of his major physiologic variables) and the disease duration, estimated here by using the hospital stay (for this pathology) duration. We show that patients inside homogeneous Diagnosis Related Groups can be...
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