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We demonstrate the detection of single protein molecules in an aqueous environment with an Yb-doped silica microlaser. With the employment of a real-time spectrum analyzer, a fast sampling speed of sub-milliseconds per spectrum was adopted.
We report the detection of 11.5-nm radius polystyrene beads in an aqueous environment at a signal-to-noise-ratio of 18:1 by monitoring the split frequency steps of a 5.7-KHz-linewidth microlaser. The thermal-optical effect is also observed.
We report nano-detection using a silica microtoroid with a reference interferometer. Single polystyrene nano-beads at a record 12.5nm radius are detected; Influenza-A virion binding events with signal-to-noise ratio exceeding 38:1 are observed.
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