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Researchers at the Air Force Research Laboratory's (AFRL) Directed Energy Directorate and magnetron engineers at Communications and Power Industries (CPI) have designed a conventional magnetron intended to deliver 1.5 MW peak power output at 920 MHz. The source was virtually prototyped using AFRL's state-of-the-art computer simulation software package, the Improved Concurrent Electromagnetic Particle...
The Buneman-Hartree (B-H) condition is reexamined in a cylindrical relativistic magnetron using both the conventional single particle model, and the Brillouin flow model. These two models yield the same result for the Buneman-Hartree condition only in the limit of a planar magnetron. In general, the B-H condition according to the Brillouin flow model allows a wider range of operating conditions, consistent...
A combination nonavalent pneumococcal–group C meningococcal conjugate vaccine (Pnc9–MenC) was previously found to be safe and immunogenic when administered to infants at 2, 3 and 4 months. This study describes the persistence of immunity at 12 months of age and the immunologic response to a challenge dose of either meningococcal polysaccharide vaccine (Meningivac A+C™; MnA+C), or MenC.A phase II,...
Two hundred forty-one healthy infants were enrolled in an open randomised controlled study of three doses of DTaP-IPV-Hib (Group 1) or DTwP/Hib+OPV (Group 2) at 2, 3 and 4 months of age given concurrently with a meningitis C conjugate vaccine. After each dose, local reactions (any grade) were less common in Group 1 than Group 2 (p<0.03). Axillary temperature >37.5°C, decreased feeding, reduced...
To date, there are no data assessing the utility of avidity indices as a surrogate marker for the induction of immunological memory following meningococcal serogroup B outer membrane vesicle (OMV) vaccination. We studied infants who had been immunized with three doses of a recombinant hexavalent PorA OMV vaccine at ages 2-4 months, together with a fourth dose at age 12-18 months. A control group had...
Abstract. Streptococcus pneumoniae the pneumococcus affects children and adults worldwide. Invasive pneumococcal disease, including pneumonia, meningitis and bacteraemia, has been linked annually to the deaths of millions of children. The pneumococcus is also a significant contributor to mucosal infections such as acute otitis media and sinusitis. Though pneumococcal infections can occur at any age,...
. Streptococcus pneumoniae– the pneumococcus– affects children and adults worldwide. Invasive pneumococcal disease, including pneumonia, meningitis and bacteraemia, has been linked annually to the deaths of millions of children. The pneumococcus is also a significant contributor to mucosal infections such as acute otitis media and sinusitis. Though pneumococcal infections can occur at any age, persons...
The introduction of meningococcal serogroup C conjugate vaccines into the UK immunisation schedule has led to the decline of serogroup C disease in those vaccinated but there is no imminent vaccine solution for serogroup B disease. The PorA outer membrane protein (OMP) is a potential serogroup B vaccine candidate and an outer membrane vesicle (OMV) vaccine containing six different PorA OMPs (each...
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