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The goal of this study was to develop an algorithm to semi-automatically segment the meniscus in a series of magnetic resonance (MR) images to use for normal knees and those with moderate osteoarthritis (OA).The segmentation method was developed then evaluated on 10 baseline MR images obtained from subjects with no evidence, symptoms, or risk factors of knee (OA), and 14 from subjects with established...
In this paper we explore a method of segmentation of muscle interstitial adipose tissue (IAT) in MR images of the thigh. The objective is to apply the method towards research into biomarkers of osteoarthritis (OA). T1-weighted images of the thigh are intensity standardized through bias field correction and intensity normalization. IAT within the thigh muscles is then segmented using a threshold combined...
We present a preliminary evaluation of an automated segmentation method of the quadriceps muscles from MR images of the thigh. The method is being developed to assist research into morphological properties of the quadriceps muscles as biomarkers of osteoarthritis (OA) incidence and progression. Our method uses an anatomically anchored, template-based initialization of the level set-based segmentation...
In this paper we develop a fully automated method for the segmentation of the femur in axial MR images and its use in the analysis of imaging biomarkers for osteoarthritis (OA). The proposed method is based on anatomical constraints implemented using morphological operations to extract the femur medulla and a level set evolution to extract the femur cortex. The average agreement of the automated segmentation...
The molecular defect responsible for dilated cardiomyopathy (DCM) remains elusive. Despite several loci having been mapped for DCM, no gene has been identified. In DCM of muscular dystrophies, while genes have been found, the responsible molecular mechanism is unknown. In myotonic dystrophy (DM) the genetic defect, excess triplet repeats (CTG) in the 3' end of myotonin protein kinase (Mt-PK), is...
The steady-state oxidation of ferrocytochrome c by cytochrome oxidase monitored spectrophotometrically showed that: (1) the kinetics were strictly biphasic with purified enzyme, while mitochondrial membrane-bound enzyme exhibited multiphasic kinetics with extended low affinity phases; (2) the TN max for the highest affinity phase was as slow as 5-10 electron . s -1 for...
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