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Major advances in the understanding in the biological sciences have been achieved by the precision automation of repetitive analytical procedures. The requirements for precision are pushed to the extreme when considering the analysis of cell function at the single cell level. Such analyses may include examination of gene expression, protein synthesis, and metabolic activity. The repetitive nature...
A novel system that has enabled the measurement of single-cell oxygen consumption rates is presented. The experimental apparatus includes a temperature controlled environmental chamber, an array of microwells etched in glass, and a lid actuator used to seal cells in the microwells. Each microwell contains an oxygen sensitive platinum phosphor sensor used to monitor the cellular metabolic rates. Custom...
Advancements in methods and algorithms for the measurement of oxygen consumption rates of single cells is presented. In this system a low density of randomly seeded eukaryotic cells are sealed in an array of microwells etched in glass (zero to three cells per microwell). The decrease in oxygen concentration inside each microwell in the array is measured yielding the oxygen consumption rates of the...
The analysis of cell function comprises an examination of gene expression, protein synthesis, and metabolic activity. In order to measure these parameters in single cells a means for signal transduction and amplification is required. Fluorescent molecules have been demonstrated to provide a powerful tool for this detection need when performing living cell analysis. The development of an image analysis...
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