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Background The introduction of highly effective direct-acting antiviral (DAA) therapy for hepatitis C has led to calls to eliminate it as a public health threat through treatment-as-prevention. Recent studies suggest it is possible to develop a vaccine to prevent hepatitis C. Using a mathematical model, we examined the potential impact of a hepatitis C vaccine on the feasibility and cost of achieving...
The development of microscale surgical tools could pave the way for truly minimally invasive microsurgical procedures. This work demonstrates the application of direct laser writing (DLW) using two-photon polymerization (TPP), a rapid prototyping microfabrication technique, to create a tethered, passively actuated three-dimensional gripper with potential applications in microbiopsy. A microgripper...
In the multiuser MIMO broadcast channel, the use of precoding techniques is required in order to detect the signal at the users' terminals without any cooperation between them. This contribution presents the design and hardware implementation of a high-capacity precoder based on vector perturbation. The most challenging part of the vector precoding (VP) scheme, that is, the search for the perturbing...
This paper presents an open-bounded case study of our Viable Computer System (VCS), the design grammar model innovating a hybrid VCS architectural representation of Beer's cybernetic Viable System Model (VSM). When applied to a previous genetically-modified system scenario, System One represents a metaphor for homeostasis. The set-theoretical framework defines research specifics, i.e. systems and...
This paper presents a case study considering algorithmic hot swapping in the context of research surpassing Autonomic Computing, towards Viable Computing Systems. Cybernetic, mathematical and biological metaphors are allied to the human autonomic agent capability of the managerial cybernetics underscoring Beer's Viable System Model (VSM). A dual-perspective set theory design grammar model is employed...
This letter offers a statistical analysis of the basic two-hop Amplify-and-Forward link, where the relay node is selected based on instantaneous and partial knowledge of the channel. In contrast with previously reported work, where relay selection requires global knowledge (2 hops) of the relaying link, the problem considered is interesting in practical ad-hoc systems, where only neighboring (1 hop)...
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