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Hintergrund In den letzten Jahrzehnten ist weltweit ein stetiger Rückgang der Autopsiezahlen zu verzeichnen. Die Gründe dafür sind vielfältig. Die Gesetzgebung bzgl. Widerspruchs- bzw. Zustimmungsregelung scheint keinen wesentlichen Einfluss auf die Autopsierate zu haben. Vor allem strukturelle Ursachen und die Einstellung der Ärzteschaft sind Gründe für diesen Rückgang. Als Hauptargument für eine...
We report the sequence of the Halobacterium salinarum strain R1 chromosome and its four megaplasmids. Our set of protein-coding genes is supported by extensive proteomic and sequence homology data. The structures of the plasmids, which show three large-scale duplications (adding up to 100 kb), were unequivocally confirmed by cosmid analysis. The chromosome of strain R1 is completely colinear and virtually...
The genomic signal analysis of nucleotide sequences reveals features difficult to identify using only the symbolic representation in the genomic data bases. Some genomic signal features correlate well with functional features at phenotype level. The paper presents results of GSA applied in the study of Mycobacteriumtuberculosis rpoB gene mutations known to confer rifampin resistance.
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