Search results for: J.D. Pearson

Items from 1 to 11 out of 11 results

article

Computational design of thin-film nanocomposite coatings for optimized stress and velocity accommodation response

J.D. Pearson, M.A. Zikry, K. Wahl

Wear > 2009 > 267 > 5-8 > 1137-1145

The tailoring of thin-film coatings comprised of high strength nano-grained constituents is investigated by new microstructurally based finite-element techniques for applications related to the wear, durability, and performance of these coatings over a broad range of temperatures and loading conditions. These coatings are comprised of brittle phases, diamond-like carbon and partially stabilized zirconia...

article

168: Subgroup Analyses of Time to Antibiotics in Community-Acquired Pneumonia: Correlating Capacity and Physician-Dependent Processes With Outcomes

J.D. Pearson, W. Novicoff, T.P. Buckley, W.J. Brady, more

Annals of Emergency Medicine > 2008 > 52 > 4 Supplement > S94-S95

article

Neutrophils in development of multiple organ failure in sepsis

KA Brown, SD Brain, JD Pearson, JD Edgeworth, more

The Lancet > 2006 > 368 > 9530 > 157-169

Multiple organ failure is a major threat to the survival of patients with sepsis and systemic inflammation. In the UK and in the USA, mortality rates are currently comparable with and projected to exceed those from myocardial infarction. The immune system combats microbial infections but, in severe sepsis, its untoward activity seems to contribute to organ dysfunction. In this Review we propose that...

article

Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia

C. Aguayo, J. Casado, M. González, J.D. Pearson, more

Placenta > 2005 > 26 > 8-9 > 641-653

Human equilibrative, Na ⁺ -independent nucleoside transport is mediated by membrane proteins sensitive (system es, hENT1) or insensitive (system ei, hENT2) to nitrobenzylthioinosine (NBMPR). Gestational diabetes and elevated extracellular concentrations of d-glucose reduce adenosine transport in human umbilical vein endothelium (HUVEC). We studied hENT2 and hENT1 expression in HUVEC, and the...

article

Natural History of Progression After PSA Elevation Following Radical Prostatectomy

C.R. Pound, A.W. Partin, M.A. Eisenberger, D.W. Chan, more

The Journal of Urology > 1999 > 162 > 4 > 1548

article

The haemodynamic effects of iodinated water soluble radiographic contrast media: a review

S.K. Morcos, P. Dawson, J.D. Pearson, J.Y. Jeremy, more

European Journal of Radiology > 1998 > 29 > 1 > 31-46

All classes of iodinated water-soluble radiographic contrast media (RCM) are vasoactive with the iso-osmolar dimers inducing the least changes in the vascular tone. The mechanisms responsible for RCM-induced changes in the vascular tone are not fully understood and could be multifactorial. A direct effect on the vascular smooth muscle cells causing alterations in the ion exchanges across the cell...

article

Human IgG xenoreactive antibodies mediate damage to porcine endothelial cells in vitro by both humoral and cellular mechanisms

SP Cooke, JD Pearson, COS Savage

Transplant Immunology > 1997 > 5 > 1 > 39-44

A major barrier to the transplantation of a porcine organ into a human recipient is the hyperacute rejection response which has been shown to be mediated by xenoreactive antibodies (XAb) and complement proteins. Here, evidence is presented that normal human sera contain IgG XAb that are able to mediate increased adhesion of polymorphonuclear leucocytes (PMN) to porcine aortic endothelial cells (PAEC)...

article

Histone H4 stimulates glucose uptake through the insulin receptor

LL Louters, DE Michele, JD Pearson

Biochimie > 1996 > 78 > 1 > 39-45

Histone H4 stimulates the uptake of glucose in rat adipocytes and muscle cells. However, the mechanism of this unusual activity is not known. Therefore, we have begun to investigate the mechanism by which histone H4 stimulates the glucose uptake in rat adipocytes. We report that histone H4 requires 15-20 min to achieve its maximum effect and its time course is virtually indistinguishable from the...

article

Detuning effects in parametric amplifiers

K.L. Hughes, B.S. Lee, D. Lynes, J.D. Pearson

Electronics Letters > 1965 > 1 > 5 > 117 - 118

Some detuning effects in parametric amplifiers have been observed when the pump frequency is above and below the optimum value. A possible explanation of these effects is suggested.

article

"The Production Engineer in a Changing Economy". North Midlands Regional Conference, 23rd April, 1960

J.D. Pearson, F. Morley, H. Burke

Production Engineer > 1960 > 39 > 8 > 461 - 467

article

A 20 kW pulsed travelling-wave tube

J.D. Pearson, H.S. Cockroft

Proceedings of the IEE - Part B: Radio and Electronic Engineering > 1958 > 105 > 10-S > 458 - 463

A sealed-off S-band travelling-wave tube has been made with an efficiency greater than 20% and a saturation output power of 40 kW. The interaction circuit was a ring-and-bar structure operating with a 25kV beam. The tube was required to be stable under short-circuit operation and to have a high mean power-handling capacity. The attenuator problem was tackled by splitting the structure into two parts,...

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