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We evaluated the use of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) for the rapid identification of anaerobic bacteria that had been isolated from clinical specimens and previously identified by 16s rRNA sequencing. The Bruker Microflex MALDI-TOF instrument with the Biotyper Software was used. We tested 152 isolates of anaerobic bacteria from 24 different...
In this paper, we introduce a novel feature selection method that combines ant colony optimization (ACO) with support vector machine (SVM) to identify candidate biomarkers from mass spectral serum profiles. In addition, we present an innovative rule extraction algorithm that uses ACO to select accurate if-then rules for the classification of mass spectra. We applied the proposed feature selection...
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