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Abusive head trauma (AHT) is a potentially fatal result of child abuse but the mechanisms of injury are controversial. To address the hypothesis that shaking alone is sufficient to elicit the injuries observed, effective computational and experimental models are necessary. This paper investigates the use of a coupled rigid-body computational modelling framework to reproduce in vivo shaking kinematics...
In this study a three-dimensional discrete fibre model was developed to provide insights into the important structure-function relationship in skin tissue. A structural approach determines the macroscopic mechanical response of the tissue from its underlying structural components. A network of collagen fibres was embedded into a tissue block of tissue. A family of fibres with varying orientations...
Patient-specific models of the biomechanics of the breast based on finite deformation theory is potentially a valuable tool to assist clinicians in assimilating and assessing information obtained from different views of the breast, under different loading conditions and using different imaging modalities. It is anticipated that a computational model of the large deformation mechanics of the breast...
Patient-specific models of the biomechanics of the breast based on finite deformation theory is potentially a valuable tool to assist clinicians in assimilating and assessing information obtained from different views of the breast, under different loading conditions and using different imaging modalities. It is anticipated that a computational model of the large deformation mechanics of the breast...
Patient-specific models of the biomechanics of the breast based on finite deformation theory is potentially a valuable tool to assist clinicians in assimilating and assessing information obtained from different views of the breast, under different loading conditions and using different imaging modalities. It is anticipated that a computational model of the large deformation mechanics of the breast...
Non-rigid-body registration techniques, that constrain the set of possible soft tissue deformations to be consistent with the basic laws of physics, offer a means of providing realistic and accurate estimates of breast movement under mammographic compression. Such constraints can be imposed by the use of anatomically accurate finite element models that predict soft tissue deformations. The overarching...
A 3D reconstruction microscope has been built in order to investigate the structural details of the airway tree and the vasculature of mouse lungs. The objective is to create an anatomically correct finite element model of a mouse lung in order to validate results from simulations obtained using an existing model of the human lung. The 3D reconstruction microscope consists of a fully automated scanning...
A multiaxial testing rig has been designed to investigate mechanical properties of soft tissue membranes. This approach has the advantage over biaxial loading in that it can be used to investigate soft tissue membranes with complex structural architecture. A finite element model of tissue mechanics has been used to analyze the experimental data in order to evaluate the stress-strain relationship,...
A typical breast cancer examination involves the comparison of image patterns in mammograms of craniocaudal (CC) and mediolateral oblique (MLO) views. Obtaining these mammograms requires the compression of the breast in two different directions. During compression, breast tissues undergo large deformations and hence the CC and MLO views do not show exactly the same region of the breast. Nonrigid body...
Measurement of the energy consumption of isolated cardiac muscle requires a flow-through microcalorimeter with sensitivity in the /spl mu/W range. In this paper we describe and characterize a sensitive flow-through microcalorimeter, designed and constructed for measuring the heat output of cardiac trabeculae. The device exploits a non-contact, temperature-sensing technique utilizing infra-red-sensitive,...
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