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Genetic inactivation of monoamine oxidase-A (MAO-A) significantly elevates levels of serotonin (5-HT) during early development and causes a disruption in the compartmented organization of thalamocortical axon terminals in layer 4 of the somatosensory cortex. In order to determine whether corticocortical innervation of the primary somatosensory cortex is also affected by this mutation, we examined...
A study was undertaken to compare the efficacy of plasmid constructs encoding human IFN-α2 and IFN-β and macaque IFN-β against herpes simplex virus type 1 in transfected cells. All type I IFN transgenes significantly reduced viral titers in transfected cells by 3 logs. Human IFN-α2-transfected cells produced significantly more IFN (2274 pg/ml) in comparison to IFN-β-transfected cells (134–165 pg/ml)...
To explore the possibility of conferring a long-term resistance against human immunodeficiency virus (HIV) by a low continuous production of interferon-β (IFN-β) in hematopoietic progenitor cells, we transduced the human CD34 + TF-1 cells with a retroviral vector ensuring IFN-β production. The IFN-β-transduction of TF-1 cells resulted in resistance to infection with HIV-LAI, as shown by the...
In a transgenic mouse line (Tg8) deficient for the gene encoding monoamine oxidase A (MAOA), we show that the primary somatosensory cortex (S1) lacks the characteristic barrel-like clustering of layer IV neurons, whereas normal pattern formation exists in the thalamus and the trigeminal nuclei. No barrel-like patterns were visible with tenascin or serotonin immunostaining or with labeling of thalamocortical...
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