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Chimeric molecules expressing multiple copies of the loop-forming hemagglutinin noose epitope (designated as “L”; aa386–400), a protective B cell epitope of the measles virus were generated by recombinant technology. The recombinant polyepitope [L 4 T 4 ] 2 combining two sets of four repeats of the L epitope and with two sets of four repeats of the human promiscuous T cell...
The loop comprising aminoacids H236–256, connects two strands of sheet 1 of the propeller-like hemagglutinin (H) protein of the measles virus (MV) and contains a putative active site residue (R253), a residue implicated in CD46-downregulation (R243) and the minimal epitope E245L–QL249 of the neutralising and protective monoclonal antibody BH129. The objective of this study was to design synthetic...
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