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Recent reports have revealed that hydrogen sulfide (H2S) has emerged as the most recent endogenous gasotransmitter involved many physiological and pathological processes. The pathways involved in the production, consumption, and mechanism of action of H2S appear to be sensitive to alterations in the redox stress. Thiosulfate (S2O32–) is one of oxidized products of the sulfide pathway, and has been...
Aims/hypothesis We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axon guidance receptor, homologue 1 (Drosophila) (ROBO1) interactions. Methods C-X-C...
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