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Infectious cercariae of Schistosoma mansoni gain entry to the mammalian host through the skin where they induce a transient inflammatory influx of mononuclear cells. Some of these cells have antigen-presenting cell function (MHCII + ) and have been reported to migrate to the skin-draining lymph nodes (sdLN) where they have the potential to prime CD4 + cells of the acquired immune response...