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Aim
To determine whether metformin's effects on carotid artery intima‐media thickness (cIMT) in type 1 diabetes differ according to smoking status.
Methods
Regression model effect estimates for the effect of metformin versus placebo (double‐blind) on carotid IMT were calculated as a subgroup analysis of the REMOVAL trial.
Results
In 428 randomized participants (227 never‐smokers, 201 ever‐smokers),...
Objective
To determine the effect of (1) an oral fat load and (2) pro‐protein convertase subtilisin/kexin type (PCSK) 9 loss‐of‐function (LOF) variant status on the ability of peripheral blood mononuclear cells (PBMC) to inhibit human adipogenesis.
Methods
PBMC from subjects with one or more PCSK9 LOF variants versus non‐variant controls were compared in the fasting state and after an oral fat...
Autosomal dominant familial hypercholesterolemia (FH) is caused by genetic mutations in the LDL receptor (LDLR), its ligand apolipoprotein (apo) B, or proprotein convertase subtilisin/kexin type 9 (PCSK9). Although PCSK9 levels have been shown to correlate with LDL-cholesterol (LDL-C) levels in FH, the extent to which PCSK9 levels modulate the phenotypic severity of this disease independent of LDLR...
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