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Tumour burden is a prognostic biomarker in metastatic melanoma. However, tumour burden is difficult to measure and there are currently no reliable surrogate biomarkers to easily and reliably determine it. The aim of this study was to assess the potential of plasma total cell free DNA as biomarker of tumour burden and prognosis in metastatic melanoma patients.A prospective biomarker cohort study for...
Purpose
Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 30% of UM patients develop metastases, most often in the liver, and there is no therapy to either prevent or treat these metastases. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease.
In UM Cure...
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