Search results for: Menglin Cheng

Items from 1 to 12 out of 12 results

article

Nimodipine attenuates dibutyl phthalate‐induced learning and memory impairment in kun ming mice: An in vivo study based on bioinformatics analysis

Biao Yan, Ping Ma, Shaohui Chen, Hongguo Cheng, more

Environmental Toxicology > 36 > 5 > 821 - 830

Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that nimodipine (Nim) palys a neuropharmacological and psychopharmacological role in neurons, the attenuating effects of Nim on learning and memory impairment...

article

Factors associated with oral health service utilization among adults and older adults in China, 2015‐2016

Mengru Xu, Menglin Cheng, Xiaoli Gao, Huijing Wu, more

Community Dentistry and Oral Epidemiology > 48 > 1 > 32 - 41

Objectives To explore the factors associated with utilization of oral health services among Chinese adults and older adults according to the Andersen Behavior Model. Methods Data from the 4th National Oral Health Survey (2015‐2016) in China were used. A total of 7206 people (3669 adults aged 35‐44 years and 3537 older adults aged 65‐74 years) were included in our analysis. Oral health service utilization...

article

Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer

Kanchan Sonkar, Vinay Ayyappan, Caitlin M. Tressler, Oluwatobi Adelaja, more

NMR in Biomedicine > 32 > 10 > n/a - n/a

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer‐related studies have focused on phosphocholine...

article

Oral health service utilization patterns among preschool children in Beijing, China

Mengru Xu, Chao Yuan, Xiangyu Sun, Menglin Cheng, more

BMC Oral Health > 2018 > 18 > 1 > 1-9

Background The utilization of oral health services in children remains at a relatively low level in China. However, little is known about the utilization patterns and related factors. The objective of this study was to explore the patterns of oral health service utilization and to determine the related factors among preschool children in Beijing, China, based on the Andersen behavioral model. Methods...

article

Nano-silver modifies the vase life of cut herbaceous peony (Paeonia lactiflora Pall.) flowers

Daqiu Zhao, Menglin Cheng, Wenhui Tang, Ding Liu, more

Protoplasma > 2018 > 255 > 4 > 1001-1013

Herbaceous peony (Paeonia lactiflora Pall.) is a popular high-grade cut flower because of higher ornamental value. However, its short flowering time severely restricts the production and application of cut P. lactiflora flowers. In this study, nano-silver (NS) was applied to prolong the vase life of cut P. lactiflora flowers. Under the NS treatment, related physiological indices including relative...

article

Identification of geological structure which induced heavy water and mud inrush in tunnel excavation: A case study on Lingjiao tunnel

Xiaozhao Li, Peixing Zhang, Zhicheng He, Zhen Huang, more

Tunnelling and Underground Space Technology > 2017 > 69 > C > 203-208

Groundwater and mud inrush during tunneling may cause severe security risk, great economic loss and unrecoverable damage to environment. However, the prediction and prevention still remain as a challenging problem. According to geological survey, Lingjiao tunnel was judged to be safe from danger of large-scale water and mud inrush. Unfortunately, a large (the largest one in China) mud outburst accident...

article

Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

Maria Dung Cao, Menglin Cheng, Asif Rizwan, Lu Jiang, more

NMR in Biomedicine > 29 > 8 > 1098 - 1107

Abnormal choline phospholipid metabolism is associated with oncogenesis and tumor progression. We have investigated the effects of targeting choline phospholipid metabolism by silencing two glycerophosphodiesterase genes, GDPD5 and GDPD6, using small interfering RNA (siRNA) in two breast cancer cell lines, MCF‐7 and MDA‐MB‐231. Treatment with GDPD5 and GDPD6 siRNA resulted in significant increases...

article

CEST‐MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response

Kannie W. Y. Chan, Lu Jiang, Menglin Cheng, Jannie P. Wijnen, more

NMR in Biomedicine > 29 > 6 > 806 - 816

Chemical exchange saturation transfer (CEST) is an MRI contrast mechanism that detects the exchange of protons from distinct hydroxyl, amine, and amide groups to tissue water through the transfer of signal loss, with repeated exchange enhancing their effective signal. We applied CEST to detect systematically 15 common cellular metabolites in a panel of differentially aggressive human breast cancer...

article

Klotho inhibits angiotensin II-induced cardiomyocyte hypertrophy through suppression of the AT1R/beta catenin pathway

Liangzhu Yu, Wei Meng, Jieqiong Ding, Menglin Cheng

Biochemical and Biophysical Research Communications > 2016 > 473 > 2 > 455-461

Myocardial hypertrophy is an independent risk factor for cardiac morbidity and mortality. The antiaging protein klotho reportedly possesses a protective role in cardiac diseases. However, the precise mechanisms underlying the cardioprotective effects of klotho remain unknown. This study was aimed to determine the effects of klotho on angiotensin II (Ang II)-induced hypertrophy in neonatal rat cardiomyocytes...

article

Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells

Ulf D. Kahlert, Menglin Cheng, Katharina Koch, Luigi Marchionni, more

International Journal of Cancer > 138 > 5 > 1246 - 1255

Notch signaling can promote tumorigenesis in the nervous system and plays important roles in stem‐like cancer cells. However, little is known about how Notch inhibition might alter tumor metabolism, particularly in lesions arising in the brain. The gamma‐secretase inhibitor MRK003 was used to treat glioblastoma neurospheres, and they were subdivided into sensitive and insensitive groups in terms of...

article

Endothelin-1 Stimulates the Expression of L-Type Ca²⁺ Channels in Neonatal Rat Cardiomyocytes via the Extracellular Signal–Regulated Kinase 1/2 Pathway

Liangzhu Yu, Mincai Li, Tonghui She, Chunrong Shi, more

The Journal of Membrane Biology > 2013 > 246 > 4 > 343-353

The cardiac L-type Ca²⁺ channel current (I _Ca,L) plays an important role in controlling both cardiac excitability and excitation–contraction coupling and is involved in the electrical remodeling during postnatal heart development and cardiac hypertrophy. However, the possible role of endothelin-1 (ET-1) in the electrical remodeling of postnatal and diseased hearts remains unclear. Therefore, the present...

article

Integration of Light- and Brassinosteroid-Signaling Pathways by a GATA Transcription Factor in Arabidopsis

Xiao-Min Luo, Wen-Hui Lin, Shengwei Zhu, Jia-Ying Zhu, more

Developmental Cell > 2010 > 19 > 6 > 872-883

Light and brassinosteroid (BR) antagonistically regulate the developmental switch from etiolation in the dark to photomorphogenesis in the light in plants. Here, we identify GATA2 as a key transcriptional regulator that mediates the crosstalk between BR- and light-signaling pathways. Overexpression of GATA2 causes constitutive photomorphogenesis in the dark, whereas suppression of GATA2 reduces photomorphogenesis...

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