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The γ-secretase complex, composed of four non-covalently bound transmembrane proteins Presenilin, Nicastrin (NCT), APH-1 and PEN-2, is responsible for the intramembranous cleavage of amyloid precursor protein (APP), Notch and several other type I transmembrane proteins. γ-Secretase cleavage of APP releases the Aβ peptides, which form the amyloid plaques characteristic of Alzheimer's disease brains,...
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