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Pre-surgical planning of mitral valve (MV) repair in patients with Barlow's disease (BD) and fibroelastic deficiency (FED) is challenging due to inability to accurately assess the complexity of MV prolapse. We hypothesized that the etiology of degenerative MV disease (DMVD) could be objectively and accurately determined using morphologic analysis of MV geometry from real-time 3D echocardiographic...
Combined assessment of left ventricular (LV) shape and function could provide new insights into the process of LV remodeling. Real-time 3D echocardiography (RT3DE) allows rapid and accurate semi-automated extraction of LV endocardial surfaces. Our aims were to quantify LV morphology both globally and regionally, using new ellipsoidal (E), spherical (S) and conical (C) shape indices, in a large population...
Real-time 3D echocardiography (RT3DE), cardiac magnetic resonance (CMR) and cardiac computed tomography (CCT) can quantify right ventricular (RV) volume and overcome the limitations 2D echocardiography that stem from the unique geometry of the right ventricle. We tested a new technique for volumetric analysis of the right ventricle designed for RT3DE, CMR and CCT (TomTec) on images obtained in RV-shaped...
Aortic stenosis (AS) is the most common native valve disease. The assessment of its severity is routinely performed using transthoracic 2D echocardiography. In particular, aortic valve area (AVA) is usually assessed by continuity equation, although this measurement relies on geometrical assumptions, or by planimetry on transesophageal echocardiography. Accordingly, the aim of this study was to develop...
Mitral effective regurgitant orifice area (EROA) using the flow convergence (FC) method is the current method of choice for quantifying the severity of mitral regurgitation (MR). However, this methodology has limitations, especially in patients with complex mitral valve (MV) pathology. The superior image quality of the transesophageal real-time 3D echocardiography (RT3D-TEE) offers an opportunity...
Mitral valve (MV) repair is the preferential treatment for mitral regurgitation (MR) associated with degenerative MV disease, and the functional benefits of early surgery are known. Our goal was to evaluate the changes in LV shape following MV repair, using a new method based on real-time 3D echocardiography (RT3DE). Fifty patients with severe asymptomatic MR were enrolled. Transthoracic RT3DE imaging...
Combined assessment of left ventricular (LV) shape and function could provide new insights into the process of LV remodeling. Real-time 3D echocardiography (RT3DE) allows rapid and accurate semi-automated extraction of LV endocardial surfaces. Our aims were to quantify LV morphology both globally, using conical (C) and spherical (S) indexes, and locally, studying the mean curvature, in a large set...
Left ventricular (LV) volumes obtained from RT3DE datasets are underestimated compared to cardiac magnetic resonance (CMR). We sought to study the accuracy and reproducibility of this technique in a multicenter setting, the inter-institutional differences in these variables in relationship with investigatorspsila experience, and the potential sources of underestimation. 92 patients underwent CMR and...
The recently developed echocardiographic matrix array transesophageal (mTEE) transducer provides real-time 3D images of high spatial and temporal resolution that may be suitable for detailed simultaneous study of functional anatomy of the mitral and aortic valves. We developed software that detects and tracks throughout the cardiac cycle mitral and aortic annuli (MA and AoA) and tested it in 15 patients...
Tissue Doppler is used to evaluate mitral annulus (MA) dynamics. This technique has two major limitations: it is two-dimensional and angle-dependent. To solve these limitations, our aim was to develop and test a tool for automated 3D tracking and quantification of the MA motion throughout the cardiac cycle by using real-time 3D echocardiography (RT3DE). The tracking algorithm was developed using a...
Off-line 3D color-encoding was applied to the left ventricular (LV) endocardial surfaces obtained from real-time 3D echocardiographic images. Systolic regional wall motion abnormalities (RWMA) were automatically detected and the accuracy of this method was tested against expert visual interpretation of 2D echocardiographic (2DE) images (apical 2-, 3- and 4- chamber). 20 subjects with normal wall motion...
Quantitative information on regional left ventricular (LV) function from real-time 3D echocardiographic (RT3DE) images has significant clinical potential, but needs validation. Our goals were to validate these measurements against cardiac magnetic resonance (CMR) and test the feasibility of automated detection of regional wall motion (RWM) abnormalities from RT3DE data. RT3DE and CMR images were obtained...
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