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Protozoan parasites of the genus Leishmania adapt to their arthropod and vertebrate hosts through the development of defined life cycle stages. Stage differentiation is triggered by environmental stress factors and has been linked to parasite chaperone activities. Using a null mutant approach we previously revealed important, nonredundant functions of the cochaperone cyclophilin 40 in L. donovani‐...
During its life cycle, the protozoan pathogen Leishmania donovani is exposed to contrasting environments inside insect vector and vertebrate host, to which the parasite must adapt for extra‐ and intracellular survival. Combining null mutant analysis with phosphorylation site‐specific mutagenesis and functional complementation we genetically tested the requirement of the L. donovani chaperone cyclophilin...
Interferon alpha (IFN-α) belongs to the type I interferon family and consists of multiple subtypes in many species. In the mouse, there are at least 14 IFN-α genes and 3 IFN-α pseudogenes, the most recently identified of which are murine interferon-alpha 12 (MuIFN-α12), MuIFN-α13 and MuIFN-α14. To further study the biological activities of MuIFN-α12, we have produced a recombinant MuIFN-α12 (rMuIFN-α12)...
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