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We examined the rapid effects of corticosterone (CORT) on N-methyl-d-aspartate (NMDA) receptor-mediated Ca 2+ signals in adult mouse hippocampal slices by using Ca 2+ imaging technique. Application of NMDA caused a transient elevation of intracellular Ca 2+ concentration followed by a decay to a plateau within 150s. The 30min preincubation of CORT induced a significant decrease...
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