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Tay-Sachs disease is an autosomal recessive neurodegenerative disease resulting from a block in the hydrolysis of G M2 ganglioside, an intermediate in ganglioside catabolism. The mouse model of Tay-Sachs disease (Hexa -/-) has been described as behaviorally indistinguishable from wild type until at least 1 year of age due to a sialidase-mediated bypass of the metabolic defect that reduces...