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The CD2AP (CD2‐associated protein) and CIN85 (Cbl‐interacting protein of 85 kDa) adaptor proteins each employ three Src homology 3 (SH3) domains to cluster protein partners and ensure efficient signal transduction and down‐regulation of tyrosine kinase receptors. Using NMR, isothermal titration calorimetry and small‐angle X‐ray scattering methods, we have characterized several binding modes of the...
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