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Sepsis is initiated by the presence of bacteria, or their products (e.g. endotoxins), in the bloodstream. It still represents a major problem in health care due to high mortality rates and incomplete understanding of the molecular mechanisms driving the disease. The Janus kinase Tyk2 is part of the signal transduction cascade utilized by different cytokines that are crucial for innate and adaptive...
Tyrosine kinase 2 (TYK2) has a pivotal role in immunity to infection and tumor surveillance. It is associated with several cytokine receptor chains including type I interferon (IFN) receptor 1 (IFNAR1), interleukin- (IL-) 12 receptor beta 1 (IL-12Rb1) and IL-10R2. We have generated a mouse with a conditional Tyk2 null allele and proved integrity of the conditional Tyk2 locus. TYK2 was successfully...
Signal transducers and activators of transcription (STAT) 1 is a key transcription factor involved in innate and adaptive immune responses by governing the responses to interferons (IFNs) type I, II and III. In order to elucidate the cell type specific contributions of STAT1 to the host response to viral infections our lab generated conditional Stat1 mice. Cytomegalovirus (CMV) can trigger severe...
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