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Renal proximal tubule cells overexpress aromatic l-amino acid decarboxylase (AAD) to produce dopamine, which inhibits salt absorption in the hypertonic environment. We examined the effect of TonEBP on AAD expression in human proximal tubule epithelial cells, HK-2 cell line. Confocal microscopy showed that after 2h of exposure to the hypertonic medium, TonEBP accumulation in nuclei increased as compared...