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Inflammation is strongly associated with the mechanism of β-cell failure in type 2 diabetes mellitus (T2DM). Blockade of the key proinflammatory cytokine IL-1β has been implicated as a promising therapeutic strategy for the prevention and treatment of type 2 diabetes. In this study, we developed an IL-1β-targeted therapeutic vaccine consisting of an IL-1β epitope peptide (A1β) and assessed its efficacy...
We investigated whether GABA activates phospholipase A 2 (PLA 2 ) during acrosomal exocytosis, and if the MEK-ERK1/2 pathway modulates PLA 2 activation initiated by GABA, progesterone or zona pellucida (ZP). In guinea pig spermatozoa prelabelled with [ 14 C]arachidonic acid or [ 14 C]choline chloride, GABA stimulated a decrease in phosphatidylcholine (PC), and...
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