The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
It has been suggested that foam cells develop in cutaneous xanthoma from the uptake of modified LDL by the macrophage scavenger receptor. We have recently described an inherited overexpression of the scavenger receptor in monocytes of two siblings with extensive xanthelasmas and planar xanthomas. Using differential display techniques we identified increased expression of the Signal Transducer and...
Due to a genetic founder effect, five mutations in the low-density lipoprotein receptor gene account for approximately 83% of familial hypercholesterolemia (FH) diagnosed in French-Canadians. The most frequent mutation, present in 61% of heterozygotes, is a > 10 kb deletion of the 5 region of the gene that removes the promoter and the first exon, resulting in a null allele. Other less prevalent...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.