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Cell cycle checkpoints are gating mechanisms that govern cell cycle progression in the presence of DNA damage and incomplete DNA replication. TheSchizosaccharomyces pombeRad1 protein is an essential component of cell cycle checkpoints activated by both types of genomic stress. In this study, we report the isolation of a human homolog of theS. pombe RAD1gene. The hRAD1 protein is also similar to theSaccharomyces...