Search results for: Christoph Kaun

Items from 1 to 20 out of 30 results

article

The plasminogen receptor Plg‐R_KT regulates adipose function and metabolic homeostasis

Fahumiya Samad, Hongdong Bai, Nagyung Baik, Patrick Haider, more

Journal of Thrombosis and Haemostasis > 20 > 3 > 742 - 754

Background Plg‐R_KT, a unique transmembrane plasminogen receptor, enhances the activation of plasminogen to plasmin, and localizes the proteolytic activity of plasmin on the cell surface. Objectives We investigated the role of Plg‐R_KT in adipose function, metabolic homeostasis, and obesity. Methods We used adipose tissue (AT) sections from bariatric surgery patients and from high fat diet (HFD)‐induced...

article

Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

Gersina Rega-Kaun, Christoph Kaun, Benjamin Ebenbauer, Gerlinde Jaegersberger, more

Journal of Thrombosis and Thrombolysis > 2019 > 47 > 1 > 51-56

Obesity is associated with a prothrombotic milieu and an increased risk for thrombotic events. Bariatric surgery is the most effective treatment for obesity resulting in dramatic weight loss and reduced inflammation and extrinsic coagulation pathway activation. Blood samples were drawn from 60 patients undergoing Roux-en-Y gastric bypass surgery before and 1 year after the intervention. Protein C...

article

Urokinase plasminogen activator protects cardiac myocytes from oxidative damage and apoptosis via hOGG1 induction

Philipp J. Hohensinner, Nikol Takacs, Christoph Kaun, Barbara Thaler, more

Apoptosis > 2017 > 22 > 8 > 1048-1055

The role of uPA in tissue remodeling and cell migration is already well established. In addition, uPA was reported to stabilize p53, a key cell cycle control, DNA repair and apoptosis initiation protein. We aimed to determine the role of uPA-uPAR signaling towards cell survival or apoptosis in human adult cardiac myocytes (HACM). HACM were stimulated with uPA and DNA damage was inflicted by incubating...

article

Anti-thrombotic and pro-fibrinolytic effects of levosimendan in human endothelial cells in vitro

Konstantin A. Krychtiuk, Christoph Kaun, Philipp J. Hohensinner, Stefan Stojkovic, more

Vascular Pharmacology > 2017 > 90 > C > 44-50

Levosimendan is an inodilator for the treatment of acute decompensated heart failure (HF). Data from clinical studies suggest that levosimendan is particularly effective in HF due to myocardial infarction. After acute revascularization, no reflow-phenomenon is a common complication that may lead to pump failure and cardiogenic shock. Our aim was to examine whether levosimendan interferes with the...

article

Biocompatibility Assessment of a New Biodegradable Vascular Graft viaIn Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, more

Annals of Biomedical Engineering > 2016 > 44 > 11 > 3319-3334

Following the implantation of biodegradable vascular grafts, macrophages and fibroblasts are the major two cell types recruited to the host-biomaterial interface. In-vitro biocompatibility assessment usually involves one cell type, predominantly macrophages. In this study, macrophage and fibroblast mono- and co-cultures, in paracrine and juxtacrine settings, were used to evaluate a new biodegradable...

article

Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels

Anna Wonnerth, Katharina M. Katsaros, Konstantin A. Krychtiuk, Walter S. Speidl, more

Metabolism > 2014 > 63 > 5 > 647-653

Interleukin-6 (IL-6) is a key cytokine in inflammatory diseases. It exerts its biological function via binding to a homodimer of its signal transducer glycoprotein 130 (gp130). Soluble gp130 (sgp130) is the natural inhibitor of IL-6 trans-signalling. The aim of this study was to test a possible influence of the gp130 genotype on sgp130 serum levels.In two separate populations, subjects were genotyped...

article

EXTRACELLULAR ADHERENCE PROTEIN OF STAPHYLOCOCCUS AUREUS INHIBITS ATHEROSCLEROSIS IN APOE-DEFICIENT MICE

Konstantin A. Krychtiuk, Stefan P. Kastl, Walter Speidl, Svitlana Demyanets, more

Journal of the American College of Cardiology > 2014 > 63 > 12(S) > A1516

article

Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature

Svitlana Demyanets, Christoph Kaun, Richard Pentz, Konstantin A. Krychtiuk, more

Journal of Molecular and Cellular Cardiology > 2013 > 60 > Complete > 16-26

Interleukin-33 (IL-33) is a recently described member of the IL-1 family of cytokines, which was identified as a ligand for the ST2 receptor. Components of the IL-33/ST2 system were shown to be expressed in normal and pressure overloaded human myocardium, and soluble ST2 (sST2) has emerged as a prognostic biomarker in myocardial infarction and heart failure. However, expression and regulation of IL-33...

article

DELAYED RECOVERY OF MYOCARDIAL BLOOD FLOW AFTER CARDIAC STEM CELL ADMINISTRATION LIMITS CELL HOMING

Mariann Gyongyosi, Rayyan Hemetsberger, Susanne Wolbank, Christoph Kaun, more

Journal of the American College of Cardiology > 2011 > 57 > 14(S) > E912

article

Delayed Recovery of Myocardial Blood Flow After Intracoronary Stem Cell Administration

Mariann Gyöngyösi, Rayyan Hemetsberger, Susanne Wolbank, Valentin Pichler, more

Stem Cell Reviews and Reports > 2011 > 7 > 3 > 616-623

The aim of the present study was to investigate the changes in absolute myocardial blood flow (AMF) after intracoronary injections of mesenchymal SC (MSC) and compared to controls in closed-chest reperfused acute myocardial infarction (AMI) in pigs. Male MSCs, transiently transfected with Luciferase (Luc-MSC) were delivered $$ \left( {{9}.{7}\pm {1}.{2} \times {1}{0^{{6}}}} \right) $$ intracoronary...

article

Adipose tissue expression of interleukin-18 mRNA is elevated in subjects with metabolic syndrome and independently associated with fasting glucose

Thomas W. Weiss, Harald Arnesen, Marius Trøseid, Christoph Kaun, more

Wiener klinische Wochenschrift > 2011 > 123 > 21-22 > 650-654

Summary BACKGROUND: The metabolic syndrome (MetS) is a cluster of risk factors that are highly associated with increased risk for cardiovascular disease (CVD). Increased serum levels of plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6) and IL-18 have been reported to be associated with CVD. Recently, IL-18 has been shown to be predictive for cardiovascular events in subjects with MetS...

article

Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ

Svitlana Demyanets, Christoph Kaun, Kathrin Rychli, Stefan Pfaffenberger, more

Basic Research in Cardiology > 2011 > 106 > 2 > 217-231

The pleiotropic cytokine oncostatin M (OSM), a member of the glycoprotein (gp)130 ligand family, plays a key role in inflammation and cardiovascular disease. As inflammation precedes and accompanies pathological angiogenesis, we investigated the effect of OSM and other gp130 ligands on vascular endothelial growth factor (VEGF) production in human vascular smooth muscle cells (SMC). Human coronary...

article

Imaging the Migration of Therapeutically Delivered Cardiac Stem Cells

Mariann Gyöngyösi, Rayyan Hemetsberger, Susanne Wolbank, Christoph Kaun, more

JACC: Cardiovascular Imaging > 2010 > 3 > 7 > 772-775

article

INTERLEUKIN-33 IS EXPRESSED IN HUMAN ATHEROSCLEROTIC TISSUE AND INCREASES PRO-INFLAMMATORY MEDIATORS IN HUMAN ENDOTHELIAL CELLS BUT NOT IN SMOOTH MUSCLE AND CARDIAC CELLS.

Svitlana Demyanets, Christoph Kaun, Stefan Pfaffenberger, Kathrin Rychli, more

Journal of the American College of Cardiology > 2010 > 55 > 10(S) > A164.E1534

article

Hypoxia-Inducible Factor 1-Alpha Release After Intracoronary Versus Intramyocardial Stem Cell Therapy in Myocardial Infarction

Mariann Gyöngyösi, Rayyan Hemetsberger, Aniko Posa, Silvia Charwat, more

Journal of Cardiovascular Translational Research > 2010 > 3 > 2 > 114-121

We have investigated the effect of stem cell delivery on the release of hypoxia-inducible factor 1 alpha (HIF-1α) in peripheral circulation and myocardium in experimental myocardial ischemia. Closed-chest, reperfused myocardial infarction (MI) was created in domestic pigs. Porcine mesenchymal stem cells (MSCs) were cultured and delivered (9.8 ± 1.2 × 10⁶) either percutaneously NOGA-guided transendocardially...

article

Monocyte chemoattractant protein (MCP-1) is expressed in human cardiac cells and is differentially regulated by inflammatory mediators and hypoxia

Philipp J. Hohensinner, Christoph Kaun, Kathrin Rychli, Enbal Ben-Tal Cohen, more

FEBS Letters > 2006 > 580 > 14 > 3532-3538

The chemokine MCP-1 is thought to play a key role – among many other pathophysiological processes – in myocardial infarction. MCP-1 is not only a key attractant for monocytes and macrophages and as such responsible for inflammation but might also be directly involved in the modulation of repair processes in the heart. We show that cultured human cardiac cells express MCP-1 and that its expression...

article

Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro

Svitlana Demyanets, Christoph Kaun, Stefan Pfaffenberger, Philipp J. Hohensinner, more

Biochemical Pharmacology > 2006 > 71 > 9 > 1324-1330

Recent findings have implicated hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins, an established class of drugs for the treatment of hypercholesterolemia, in tissue remodeling in the heart. Statins induce apoptosis in different cell culture systems including rat neonatal cardiomyocytes. We investigated possible effects of different statins in vitro in human adult cardiac...

article

PRO-APOPTOTIC EFFECT OF HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE INHIBITORS ON HUMAN MUSCLE CELLS IN VITRO

Svitlana V Demyanets, Christoph Kaun, J Pammer, Stefan Pfaffenberger, more

Cardiovascular Pathology > 2004 > 13 > 3 Supplement > 158-159

article

CATECHOLAMINES SYNERGISTICALLY INCREASE LIPOPOLYSACCHARIDE-INDUCED EXPRESSION OF MATRIX METALLOPROTEINASE-1 AND MATRIX METALLOPROTEINASE-9 IN HUMAN MONOCYTES

Walter S Speidl, Wolfgang G Toller, Christoph Kaun, Thomas W Weiss, more

Cardiovascular Pathology > 2004 > 13 > 3 Supplement > 156

article

VASCULAR ENDOTHELIAL GROWTH FACTOR IS INCREASED BY GLYCOPROTEIN 130 LIGANDS IN HUMAN ADIPOSE TISSUE

Gersina Rega, Christoph Kaun, Thomas W Weiss, Svitlana Demyanets, more

Cardiovascular Pathology > 2004 > 13 > 3 Supplement > 103

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INFONA - science communication portal

Search results for: Christoph Kaun

The plasminogen receptor Plg‐R_KT regulates adipose function and metabolic homeostasis

Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

Urokinase plasminogen activator protects cardiac myocytes from oxidative damage and apoptosis via hOGG1 induction

Anti-thrombotic and pro-fibrinolytic effects of levosimendan in human endothelial cells in vitro

Biocompatibility Assessment of a New Biodegradable Vascular Graft viaIn Vitro Co-culture Approaches and In Vivo Model

Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels

EXTRACELLULAR ADHERENCE PROTEIN OF STAPHYLOCOCCUS AUREUS INHIBITS ATHEROSCLEROSIS IN APOE-DEFICIENT MICE

Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature

DELAYED RECOVERY OF MYOCARDIAL BLOOD FLOW AFTER CARDIAC STEM CELL ADMINISTRATION LIMITS CELL HOMING

Delayed Recovery of Myocardial Blood Flow After Intracoronary Stem Cell Administration

Adipose tissue expression of interleukin-18 mRNA is elevated in subjects with metabolic syndrome and independently associated with fasting glucose

Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ

Imaging the Migration of Therapeutically Delivered Cardiac Stem Cells

INTERLEUKIN-33 IS EXPRESSED IN HUMAN ATHEROSCLEROTIC TISSUE AND INCREASES PRO-INFLAMMATORY MEDIATORS IN HUMAN ENDOTHELIAL CELLS BUT NOT IN SMOOTH MUSCLE AND CARDIAC CELLS.

Hypoxia-Inducible Factor 1-Alpha Release After Intracoronary Versus Intramyocardial Stem Cell Therapy in Myocardial Infarction

Monocyte chemoattractant protein (MCP-1) is expressed in human cardiac cells and is differentially regulated by inflammatory mediators and hypoxia

Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro

PRO-APOPTOTIC EFFECT OF HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE INHIBITORS ON HUMAN MUSCLE CELLS IN VITRO

CATECHOLAMINES SYNERGISTICALLY INCREASE LIPOPOLYSACCHARIDE-INDUCED EXPRESSION OF MATRIX METALLOPROTEINASE-1 AND MATRIX METALLOPROTEINASE-9 IN HUMAN MONOCYTES

VASCULAR ENDOTHELIAL GROWTH FACTOR IS INCREASED BY GLYCOPROTEIN 130 LIGANDS IN HUMAN ADIPOSE TISSUE

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