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We and others have found that macrophages are capable of endo- and exocytosing iron. There is pronounced iron-sequestration in macrophages of atherosclerotic lesions. The nature of the exocytosed iron and the iron-sequestration remains unclear. Many apoptotic cells have been found in atherosclerotic lesions. The mechanism of apoptosis-induction of atheroma cells is unknown. The aims of the study...
The cytotoxicity of oxidized low density lipoprotein (oxLDL) to artery wall cells might contribute to atherosclerosis by causing cell death, presumably by both apoptosis and necrosis. After its uptake into macrophage lysosomes, oxLDL is poorly degraded, resulting in ceroid-containing foam-cells. We studied the influence of oxLDL on lysosomal enzymatic activity and, in particular, on lysosomal membrane...
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