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Objective and design In this study we investigated the role of histamine on the extramedullary hematopoiesis. Methods Male histidine decarboxylase knockout (HDC−/−) mice and wild-type mice were used (n = 5/group). Groups of mice received sublethal total-body gamma irradiation at a single dose of 4 Gy. Spleen cells were studied at different time points post-irradiation by flow cytometry, colony forming...
The role of histamine receptors in radiation-induced bone marrow (BM) regeneration was investigated with aspects of functional genomics. H1R and H2R mRNA expression increased during regeneration in both histidine decarboxylase knockout (HDC −/− ) and wild type (HDC +/+ ) mice, though to a lesser extent in HDC −/− mice. H4R mRNA expression was downregulated in both groups. Mainly...
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