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Parathyroid hormone-related protein (PTHrP) has important roles in fetal growth and development through stimulation of placental calcium transport, vasodilatation of the uteroplacental vasculature and regulation of cellular growth and differentiation. The growth restricted spontaneously hypertensive rat (SHR) has reduced fetal plasma, placental and amniotic fluid PTHrP concentrations compared to its...
Arachidonic acid mobilization by phospholipase A 2 (PLA 2 ) and subsequent prostaglandin synthesis is thought to be a pivotal event in the onset and/or maintenance of human labour. The purpose of this study was to quantify secretory PLA 2 (sPLA 2 ) and non-secretory PLA 2 enzymatic activity and type II sPLA 2 immunoreactivity in human gestational tissues...
The aim of this study was to determine the effect of an inhibitor of bacterial endotoxin, monophosphoryl lipid A (MLA), on lipopolysaccharide (LPS)-induced prostaglandin E 2 (PGE 2 ) formation by human choriodecidua explants incubated in vitro. LPS induced the release of PGE 2 from explants in a time- and dose-dependent manner (P<0.05, n=5), thus establishing the efficacy...
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