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Somatostatin possesses antisecretory and antiproliferative activity on some human tumors. We herein report that, in a human neuroblastoma cell line, the somatostatin analogue BIM 23014 inhibited mitogen-activated protein (MAP) kinase activity stimulated by either insulin-like growth factor-1, whose receptor bears a tyrosine kinase, or carbachol, which acts at a G-protein coupled receptor. In a human...
We found that two long-acting somatostatin (SST) analogues, BIM 23014 and SMS 201-995, inhibited the serum and IGF-1-stimulated 3 H-thymidine incorporation in the human small cell lung carcinoma cell line H-69 and in the human neuroblastoma cell line SY5Y. Since 3 H-thymidine incorporation is tested many hours after the drugs or the growth factors administration, we measured a much...
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